The interfacial pH of acidic degradable polymeric biomaterials and its effects on osteoblast behavior.
文献类型：期刊论文
| 作者 | Ruan, Changshun ; Hu, Nan ; Ma, Yufei ; Li, Yuxiao ; Liu, Juan ; Zhang, Xinzhou ; Pan, Haobo |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | A weak alkaline environment is established to facilitate the growth of osteoblasts. Unfortunately, this is inconsistent with the application of biodegradable polymer in bone regeneration, as the degradation products are usually acidic. In this study, the variation of the interfacial pH of poly (D, L-lactide) and piperazine-based polyurethane ureas (P-PUUs), as the representations of acidic degradable materials, and the behavior of osteoblasts on these substrates with tunable interfacial pH were investigated in vitro. These results revealed that the release of degraded products caused a rapid decrease in the interfacialpH, and this could be relieved by the introduction of alkaline segments. On the contrary, when culturing with osteoblasts, the variation of the interfacial pHrevealed an upward tendency, indicating that cell could construct the microenvironment by secreting cellular metabolites to satisfy its own survival. In addition, the behavior of osteoblasts on substrates exhibited that P-PUUs with the most PP units were better for cell growth and osteogenic differentiation of cells. This is due to the hydrophilic surface and the moderate N% in P-PUUs, key factors in the promotion of the early stages of cellular responses, and the interfacial pHcontributing to the enhanced effect on osteogenic differentiation. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12370]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | SCIENTIFIC REPORTS |
| 推荐引用方式 GB/T 7714 | Ruan, Changshun , Hu, Nan , Ma, Yufei ,et al. The interfacial pH of acidic degradable polymeric biomaterials and its effects on osteoblast behavior.[J]. SCIENTIFIC REPORTS,2017. |
| APA | Ruan, Changshun ., Hu, Nan ., Ma, Yufei ., Li, Yuxiao ., Liu, Juan .,...& Pan, Haobo.(2017).The interfacial pH of acidic degradable polymeric biomaterials and its effects on osteoblast behavior..SCIENTIFIC REPORTS. |
| MLA | Ruan, Changshun ,et al."The interfacial pH of acidic degradable polymeric biomaterials and its effects on osteoblast behavior.".SCIENTIFIC REPORTS (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。