Controlled release and biocompatibility of polymer/titania nanotube array system on titanium implants
文献类型：期刊论文
| 作者 | Tingting Wang; Zhengyang Weng; Xiangmei Liu; Kelvin W.K. Yeung; Haobo Pan; Shuilin Wu |
| 刊名 | Bioactive Materials
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Bacterial infection and tissue inflammation are the major causes of early failure of titanium-based orthopedic implants; thus, surgical implants with tunable drug releasing properties represent an appealing way to address some of these problems of bacterial infection and tissue inflammation in early age of orthopedic implants. In this work, a hybrid surface system composed of biodegradable poly(lactic-coglycolic acid) (PLGA) and titania nanotubes (TNTs) has been successfully constructed on Ti implants with the aim of preventing bacterial infection via long-term drug release. By varying the size of the TNTs and the thickness of the polymer film, the drug release profile can be tuned to achieve the optimal therapeutic action throughout the treatment time. The size of TNTs plays a dominant role in the drug loading dose of TNTs/PLGA hybrid coatings. In this work, TNTs with an average size of 80 nm can achieve the largest loading dose. Depending on the polymer thickness, significant improvement in the drug release characteristics is attained, for instance, reduced burst release (from 84% to 27%) and overall release time extended from 5 to over 40 days. In addition, the PLGA layers may favor the proliferation and osteogenesis of MC3T3-E1 mouse cells at an earlier stage. Therefore, this TNT/PLGA hybrid surface system can be employed as an effective bioplatform for improving both self-antibacterial performance and biocompatibility of Ti-based biomaterials. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/12371]  |
| 专题 | 深圳先进技术研究院_医药所 |
| 作者单位 | Bioactive Materials |
| 推荐引用方式 GB/T 7714 | Tingting Wang,Zhengyang Weng,Xiangmei Liu,et al. Controlled release and biocompatibility of polymer/titania nanotube array system on titanium implants[J]. Bioactive Materials,2017. |
| APA | Tingting Wang,Zhengyang Weng,Xiangmei Liu,Kelvin W.K. Yeung,Haobo Pan,&Shuilin Wu.(2017).Controlled release and biocompatibility of polymer/titania nanotube array system on titanium implants.Bioactive Materials. |
| MLA | Tingting Wang,et al."Controlled release and biocompatibility of polymer/titania nanotube array system on titanium implants".Bioactive Materials (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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