Bioactive interpenetrating polymer networks for improving the electrode/neural-tissue interface
文献类型：期刊论文
| 作者 | Ke DN; Zhong C; Wang LP; Lu Y; Wang LL |
| 刊名 | Electrochemistry Communications
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The neural electrode is recognized as a bridge that transduces electrical signals from or into biosignals and is thus used for various experimental and therapeutic purposes. However, a major challenge that still remains is to achieve long-term effective electrical recording and stimulation in vivo. Here, we report an investigation of electrochemically co-deposited poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate)/nerve growth factor/dexamethasone phosphate/poly(vinyl alcohol)/poly(acrylic acid) interpenetrating polymer networks for improving the electrode/neural-tissue interface. After modification, the electrodes exhibit a substantially higher capacitance and lower electrochemical impedance (reduced by ~ 96%) at 1 kHz as compared to control electrodes. Furthermore, tissue response was evaluated after a 6-week implantation in the cortex of rats. Relative to the control group, the test group show significantly lower immunostaining intensity for glial fibrillary acidic protein and higher intensity for neuronal nuclei at the electrode/neural-tissue interface. All of these characteristics are greatly desired in chronic electrophysiological applications in vivo. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/11904]  |
| 专题 | 深圳先进技术研究院_脑所 |
| 作者单位 | Electrochemistry Communications |
| 推荐引用方式 GB/T 7714 | Ke DN,Zhong C,Wang LP,et al. Bioactive interpenetrating polymer networks for improving the electrode/neural-tissue interface[J]. Electrochemistry Communications,2017. |
| APA | Ke DN,Zhong C,Wang LP,Lu Y,&Wang LL.(2017).Bioactive interpenetrating polymer networks for improving the electrode/neural-tissue interface.Electrochemistry Communications. |
| MLA | Ke DN,et al."Bioactive interpenetrating polymer networks for improving the electrode/neural-tissue interface".Electrochemistry Communications (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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