Ultrasoft microwire neural electrodes improve chronic tissue integration
文献类型：期刊论文
| 作者 | Takashi D.Y. Kozai; Zhanhong Jeff Du; X. Tracy Cui; James A. Nabityi; Xin Sally Zheng; Shawn A. Sapph; Silvia D. Luebbeng; Christi L. Kolarcik |
| 刊名 | Acta Biomaterialia
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Chronically implanted neural multi-electrode arrays (MEA) are an essential technology for recording electrical signals from neurons and/or modulating neural activity through stimulation. However, current MEAs, regardless of the type, elicit an inflammatory response that ultimately leads to device failure. Traditionally, rigid materials like tungsten and silicon have been employed to interface with the relatively soft neural tissue. The large stiffness mismatch is thought to exacerbate the inflammatory response. In order to minimize the disparity between the device and the brain, we fabricated novel ultrasoft electrodes consisting of elastomers and conducting polymers with mechanical properties much more similar to those of brain tissue than previous neural implants. In this study, these ultrasoft microelectrodes were inserted and released using a stainless steel shuttle with polyethyleneglycol (PEG) glue. The implanted microwires showed functionality in acute neural stimulation. When implanted for 1 or 8 weeks, the novel soft implants demonstrated significantly reduced inflammatory tissue response at week 8 compared to tungsten wires of similar dimension and surface chemistry. Furthermore, a higher degree of cell body distortion was found next to the tungsten implants compared to the polymer implants. Our results support the use of these novel ultrasoft electrodes for long term neural implants |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/11905]  |
| 专题 | 深圳先进技术研究院_脑所 |
| 作者单位 | Acta Biomaterialia |
| 推荐引用方式 GB/T 7714 | Takashi D.Y. Kozai,Zhanhong Jeff Du,X. Tracy Cui,et al. Ultrasoft microwire neural electrodes improve chronic tissue integration[J]. Acta Biomaterialia,2017. |
| APA | Takashi D.Y. Kozai.,Zhanhong Jeff Du.,X. Tracy Cui.,James A. Nabityi.,Xin Sally Zheng.,...&Christi L. Kolarcik.(2017).Ultrasoft microwire neural electrodes improve chronic tissue integration.Acta Biomaterialia. |
| MLA | Takashi D.Y. Kozai,et al."Ultrasoft microwire neural electrodes improve chronic tissue integration".Acta Biomaterialia (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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