History of winning remodels thalamo-PFC circuit to reinforce social dominance.
文献类型：期刊论文
| 作者 | Hu, Hailan; Zhou, Tingting; Zhu, Hong; Fan, Zhengxiao; Wang, Fei; Chen, Yang; Liang, Hexing; Yang, Zhongfei; Zhang, Lu; Lin, Longnian |
| 刊名 | SCIENCE
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Mental strength and history of winning play an important role in the determination of social dominance. However, the neural circuits mediating these intrinsic and extrinsic factors have remained unclear. Working in mice, we identified a dorsomedial prefrontal cortex (dmPFC) neural population showing "effort"-related firing during moment-to-moment competition in the dominance tube test. Activation or inhibition of the dmPFC induces instant winning or losing, respectively. In vivo optogenetic-based long-term potentiation and depression experiments establish that the mediodorsal thalamic input to the dmPFC mediates long-lasting changes in the social dominance status that are affected by history of winning. The same neural circuit also underlies transfer of dominance between different social contests. These results provide a framework for understanding the circuit basis of adaptive and pathological social behaviors. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/11910]  |
| 专题 | 深圳先进技术研究院_脑所 |
| 作者单位 | SCIENCE |
| 推荐引用方式 GB/T 7714 | Hu, Hailan,Zhou, Tingting,Zhu, Hong,et al. History of winning remodels thalamo-PFC circuit to reinforce social dominance.[J]. SCIENCE,2017. |
| APA | Hu, Hailan.,Zhou, Tingting.,Zhu, Hong.,Fan, Zhengxiao.,Wang, Fei.,...&Wang, Zheng.(2017).History of winning remodels thalamo-PFC circuit to reinforce social dominance..SCIENCE. |
| MLA | Hu, Hailan,et al."History of winning remodels thalamo-PFC circuit to reinforce social dominance.".SCIENCE (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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