Astrocytic L-Lactate Signaling Facilitates Amygdala-Anterior Cingulate Cortex Synchrony and Decision Making in Rats
文献类型：期刊论文
| 作者 | Jun Wang; Jie Tu; Bing Cao; Li Mu; Xiangwei Yang; Mi Cong; Aruna S. Ramkrishnan; Rosa H.M. Chan; Liping Wang; Ying Li |
| 刊名 | Cell Reports
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Human brain imaging studies have revealed the anterior cingulate cortex (ACC) as a key brain region for mediating visceral-pain-cognitive interactions. Recently, we characterized impairments of longterm potentiation and spike-field coherence in the basolateral amygdala (BLA)-ACC network in association with a decision-making deficit in rats with visceral hypersensitivity (VH). Now, by combining integrative neurobiological approaches, we show that ACC-reactive astrogliosis and activity-dependent impairment of lactate release occur in VH rats. Exogenous lactate supply rescues chronic-visceralpain-caused impairments of ACC phase locking and decision making, which can be mimicked by optogenetic activation of ACC astrocytes. Largescale electrophysiological recordings in free-moving animals during a decision-making task indicate that optogenetic astrocytic activation improves decision-making performance and engages ACC phase locking and BLA-to-ACC information flow. Collectively, these observations support the idea of an ‘‘astrocyte-neuron L-lactate shuttle’’ and suggest that targeting astrocytes may help with cognitive dysfunctions under chronic visceral pain. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/11913]  |
| 专题 | 深圳先进技术研究院_脑所 |
| 作者单位 | Cell Reports |
| 推荐引用方式 GB/T 7714 | Jun Wang,Jie Tu,Bing Cao,et al. Astrocytic L-Lactate Signaling Facilitates Amygdala-Anterior Cingulate Cortex Synchrony and Decision Making in Rats[J]. Cell Reports,2017. |
| APA | Jun Wang.,Jie Tu.,Bing Cao.,Li Mu.,Xiangwei Yang.,...&Ying Li.(2017).Astrocytic L-Lactate Signaling Facilitates Amygdala-Anterior Cingulate Cortex Synchrony and Decision Making in Rats.Cell Reports. |
| MLA | Jun Wang,et al."Astrocytic L-Lactate Signaling Facilitates Amygdala-Anterior Cingulate Cortex Synchrony and Decision Making in Rats".Cell Reports (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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