Electrically Controlled Neurochemical Release from Dual-Layer Conducting Polymer Films for Precise Modulation of Neural Network Activity in Rat Barrel Cortex
文献类型：期刊论文
| 作者 | Zhanhong Jeff Du; Guoqiang Bi; Xinyan Tracy Cui |
| 刊名 | Advanced Functional Materials
 |
| 出版日期 | 2018 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Implantable microelectrode arrays (MEAs) are important tools for investigating functional neural circuits and treating neurological diseases. Precise modulation of neural activity may be achieved by controlled delivery of neurochemicals directly from coatings on MEA electrode sites. In this study, a novel dual-layer conductive polymer/acid functionalized carbon nanotube (fCNT) microelectrode coating is developed to better facilitate the loading and controlled delivery of the neurochemical 6,7-dinitroquinoxaline-2,3-dione (DNQX). The base layer coating is consisted of poly(3,4-ethylenedioxythiophene/fCNT and the top layer is consisted of polypyrrole/fCNT/DNQX. The dual-layer coating is capable of both loading and electrically releasing DNQX and the release dynamic is characterized with fluorescence microscopy and mathematical modeling. In vivo DNQX release is demonstrated in rat somatosensory cortex. Sensory-evoked neural activity is immediately (<1s) and locally (<446 μm) suppressed by electrically triggered DNQX release. Furthermore, a single DNQX-loaded, dual-layer coating is capable of inducing effective neural inhibition for at least 26 times without observable degradation in efficacy. Incorporation of the novel drug releasing coating onto individual MEA electrodes offers many advantages over alternative methods by increasing spatial-temporal precision and improving drug selection flexibility without increasing the device’s size. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000428347700020 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/11916]  |
| 专题 | 深圳先进技术研究院_脑所 |
| 作者单位 | Advanced Functional Materials |
| 推荐引用方式 GB/T 7714 | Zhanhong Jeff Du,Guoqiang Bi,Xinyan Tracy Cui. Electrically Controlled Neurochemical Release from Dual-Layer Conducting Polymer Films for Precise Modulation of Neural Network Activity in Rat Barrel Cortex[J]. Advanced Functional Materials,2018. |
| APA | Zhanhong Jeff Du,Guoqiang Bi,&Xinyan Tracy Cui.(2018).Electrically Controlled Neurochemical Release from Dual-Layer Conducting Polymer Films for Precise Modulation of Neural Network Activity in Rat Barrel Cortex.Advanced Functional Materials. |
| MLA | Zhanhong Jeff Du,et al."Electrically Controlled Neurochemical Release from Dual-Layer Conducting Polymer Films for Precise Modulation of Neural Network Activity in Rat Barrel Cortex".Advanced Functional Materials (2018). |
入库方式： OAI收割
来源：深圳先进技术研究院
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