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Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward
文献类型：期刊论文
| 作者 | Pei Cao; Zhijian Zhang; Qing Liu; Pengjie Wen; Jiaozhen Zhang; Xiaoping Rao; Ziming Zhou; Hongruo Zhang; Xiaobin He; Juan Li |
| 刊名 | eLife
 |
| 出版日期 | 2017 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Odor-preferences are usually influenced by life experiences. However, the neural circuit mechanisms remain unclear. The medial olfactory tubercle (mOT) is involved in both reward and olfaction, while the ventral tegmental area (VTA) dopaminergic (DAergic) neurons are considered to be engaged in reward and motivation. Here, we found that the VTA (DAergic)-mOT pathway could be activated by different types of naturalistic rewards as well as odors in DAT-cre mice. Optogenetic activation of the VTA-mOT DAergic fibers was able to elicit preferences for space, location and neutral odor, while pharmacological blockade of the dopamine receptors in the mOT fully prevented the odor-preference formation. Furthermore, inactivation of the mOT-projecting VTA DAergic neurons eliminated the previously formed odor-preference and strongly affected the Go-no go learning efficiency. In summary, our results revealed that the VTA (DAergic)-mOT pathway mediates a variety of naturalistic reward processes and different types of preferences including odor-preference in mice. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000423033300001 |
| 源URL | [http://ir.siat.ac.cn:8080/handle/172644/11919]  |
| 专题 | 深圳先进技术研究院_脑所 |
| 作者单位 | eLife |
| 推荐引用方式 GB/T 7714 | Pei Cao,Zhijian Zhang,Qing Liu,et al. Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward[J]. eLife,2017. |
| APA | Pei Cao.,Zhijian Zhang.,Qing Liu.,Pengjie Wen.,Jiaozhen Zhang.,...&Fuqiang Xu.(2017).Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward.eLife. |
| MLA | Pei Cao,et al."Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward".eLife (2017). |
入库方式： OAI收割
来源：深圳先进技术研究院
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