Activity-guided isolation of triterpenoid acyl CoA cholesteryl acyl transferase (ACAT) inhibitors from Ilex kudincha
文献类型：期刊论文
| 作者 | Nishimura, K; Fukuda, T; Miyase, T; Noguchi, H; Chen, XM; Miyase, T, Univ Shizuoka, Sch Pharmaceut Sci, 52-1 Yada, Shizuoka 4228526, Japan. |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 1999 |
| 卷号 | 62期号:7页码:1061_1064 |
| ISSN号 | 0163-3864 |
| 产权排序 | 3 |
| 英文摘要 | Activity-guided fractionation of a methanol extract of the leaves of Ilex kudincha led to the isolation of seven acyl CoA cholesteryl acyl transferase (ACAT) inhibitory triterpenes. Four of them were identified by spectroscopic methods as ulmoidol (4), 23-hydroxyursolic acid (5), 27-trans-p-coumaroyloxyursolic acid (6) and 27-cis-p-coumaroyloxyursolic acid (7), and three were new compounds named ilekudinols A-C (1-3). The structures of these new triterpenoids were elucidated as 2 alpha,3 beta-dihydroxy-24-nor-urs-4(23),11-dien-28,13 beta-olide (1), 2 alpha,3 beta-dihydroxy-24-nor-urs-4(23), 12-dien-28-oic acid (2), and 3 beta,24,28-trihydroxylupane (3). Compounds 1-7 showed potent inhibitory activity in the ACAT assay. |
| 学科主题 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000081649000034 |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/17051]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 通讯作者 | Miyase, T, Univ Shizuoka, Sch Pharmaceut Sci, 52-1 Yada, Shizuoka 4228526, Japan. |
| 推荐引用方式 GB/T 7714 | Nishimura, K,Fukuda, T,Miyase, T,et al. Activity-guided isolation of triterpenoid acyl CoA cholesteryl acyl transferase (ACAT) inhibitors from Ilex kudincha[J]. JOURNAL OF NATURAL PRODUCTS,1999,62(7):1061_1064. |
| APA | Nishimura, K,Fukuda, T,Miyase, T,Noguchi, H,Chen, XM,&Miyase, T, Univ Shizuoka, Sch Pharmaceut Sci, 52-1 Yada, Shizuoka 4228526, Japan..(1999).Activity-guided isolation of triterpenoid acyl CoA cholesteryl acyl transferase (ACAT) inhibitors from Ilex kudincha.JOURNAL OF NATURAL PRODUCTS,62(7),1061_1064. |
| MLA | Nishimura, K,et al."Activity-guided isolation of triterpenoid acyl CoA cholesteryl acyl transferase (ACAT) inhibitors from Ilex kudincha".JOURNAL OF NATURAL PRODUCTS 62.7(1999):1061_1064. |
入库方式： OAI收割
来源：成都生物研究所
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