Novel synthesis of 12,13-seco norditerpenoid alkaloids via semipinacol rearrangement and reaction with Br-2-HOAc
文献类型：期刊论文
| 作者 | Wang, FP; Chen, QH; Li, BG; Wang, FP, W China Univ Med Sci, Sch Pharm, Dept Chem Med Nat Prod, Chengdu 610041, Peoples R China. |
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2001 |
| 卷号 | 57期号:22页码:4705_4712 |
| 关键词 | Norditerpenoid Alkaloid Semi-pinacol Rearrangement Aromatization 12 13-seco Norditerpenoid Alkaloid |
| ISSN号 | 0040-4020 |
| 产权排序 | 2 |
| 英文摘要 | Treatment of 14-methylsulfonyl pseudaconine 3 with DMF-NaOH at 150 degreesC for 10 h afforded the desired C-nor and 12,13-seco norditerpenoid alkaloids 16 alpha -methoxyl ketone 7 (70%) and 16 beta -methoxyl ketone 8 (15%) as a pair of epimers. Reaction of 7 with Br-2-HOAc at room temperature for 1.5-2 h produced the phenols 9 (40%), 10 (10%) and 13 (29%). Whereas, treatment of 8 with Br-2-HOAc under same conditions as the case for 7 gave phenolic compound 9 (38%) besides the by-product alpha -bromoketone 14 (25%). (C) 2001 Elsevier Science Ltd. All rights reserved. |
| 学科主题 | Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000169029800006 |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/17205]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 通讯作者 | Wang, FP, W China Univ Med Sci, Sch Pharm, Dept Chem Med Nat Prod, Chengdu 610041, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Wang, FP,Chen, QH,Li, BG,et al. Novel synthesis of 12,13-seco norditerpenoid alkaloids via semipinacol rearrangement and reaction with Br-2-HOAc[J]. TETRAHEDRON,2001,57(22):4705_4712. |
| APA | Wang, FP,Chen, QH,Li, BG,&Wang, FP, W China Univ Med Sci, Sch Pharm, Dept Chem Med Nat Prod, Chengdu 610041, Peoples R China..(2001).Novel synthesis of 12,13-seco norditerpenoid alkaloids via semipinacol rearrangement and reaction with Br-2-HOAc.TETRAHEDRON,57(22),4705_4712. |
| MLA | Wang, FP,et al."Novel synthesis of 12,13-seco norditerpenoid alkaloids via semipinacol rearrangement and reaction with Br-2-HOAc".TETRAHEDRON 57.22(2001):4705_4712. |
入库方式： OAI收割
来源：成都生物研究所
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