Dinuclear macrocyclic polyamine zinc(II) complexes linked with flexible spacers: Synthesis, characterization, and DNA cleavage
文献类型：期刊论文
| 作者 | Peng, W; Liu, PY; Jiang, N; Lin, HH; Zhang, GL; Liu, Y; Yu, XQ; Lin, HH, Sichuan Univ, Coll Life Sci, Chengdu 610064, Peoples R China. |
| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2005 |
| 卷号 | 33期号:5页码:374_385 |
| 关键词 | Macrocyclic Polyamine Dinuclear Complexes Puc 19 Dna Cleavage 1 4 7 10-tetraazacyclododecane (Cyclen) |
| ISSN号 | 0045-2068 |
| 产权排序 | 3 |
| 英文摘要 | Dinuclear macrocyclic polyamine zinc(II) complexes, which have two cyclen groups linked by flexible spacers, have been synthesized as DNA cleavage agents. The structures of these new dinuclear complexes are consistent with the data obtained from elemental analysis, MS and I H NMR spectroscopy. The catalytic activity of these dinuclear complexes on DNA cleavage was studied. The results showed that the dinuclear zinc(II) complexes can catalyze the cleavage of supercoiled DNA (pUC 19 plasmid DNA) (Form I) under physiological conditions to produce selectively nicked DNA (Form II). (c) 2005 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000232680500003 |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/17639]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 通讯作者 | Lin, HH, Sichuan Univ, Coll Life Sci, Chengdu 610064, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Peng, W,Liu, PY,Jiang, N,et al. Dinuclear macrocyclic polyamine zinc(II) complexes linked with flexible spacers: Synthesis, characterization, and DNA cleavage[J]. BIOORGANIC CHEMISTRY,2005,33(5):374_385. |
| APA | Peng, W.,Liu, PY.,Jiang, N.,Lin, HH.,Zhang, GL.,...&Lin, HH, Sichuan Univ, Coll Life Sci, Chengdu 610064, Peoples R China..(2005).Dinuclear macrocyclic polyamine zinc(II) complexes linked with flexible spacers: Synthesis, characterization, and DNA cleavage.BIOORGANIC CHEMISTRY,33(5),374_385. |
| MLA | Peng, W,et al."Dinuclear macrocyclic polyamine zinc(II) complexes linked with flexible spacers: Synthesis, characterization, and DNA cleavage".BIOORGANIC CHEMISTRY 33.5(2005):374_385. |
入库方式： OAI收割
来源：成都生物研究所
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