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The design and synthesis of bis(thiourea) ligands and their application in Pd-catalyzed Heck and Suzuki reactions under aerobic conditions
文献类型：期刊论文
| 作者 | Chen, W; Li, R; Han, B; Li, BJ; Chen, YC; Wu, Y; Ding, LS; Yang, D; Chen, W, Sichuan Univ, W China Sch Pharm, Dept Med Chem, Chengdu 610041, Peoples R China. |
| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2006 |
| 期号 | 5页码:1177_1184 |
| 关键词 | Cross-coupling Homogeneous Catalysis Palladium s Ligands |
| ISSN号 | 1434-193X |
| 产权排序 | 2 |
| 英文摘要 | New, bulky N,N-disubstituted acyclic and cyclic bis(thiourea) ligands have been designed and synthesized. Their palladium(0) complexes are very stable and are active catalysts for Heck and Suzuki coupling reactions of aryl iodides and bromides under aerobic conditions. Good TONs and TOFs were achieved in the coupling reactions [for PhI, TONs up to 1000000 and TOFs up to 200000 (h(-1)); for activated aryl bromide, TONs up to 89000]. In addition, further studies were conducted to know more about the nature of these catalysts. The active catalyst was found to be the chelate complex containing the bis(thiourea) and Pd in a 1:1 ratio. However, unlike a monothiourea, further coordination can occur to give a coordinatively saturated complex when bis(thiourea) and I'd are combined in a 2:1 ratio; this complex is catalytically inactive in coupling reactions. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006). |
| 学科主题 | Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000235821600012 |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/17843]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 通讯作者 | Chen, W, Sichuan Univ, W China Sch Pharm, Dept Med Chem, Chengdu 610041, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Chen, W,Li, R,Han, B,et al. The design and synthesis of bis(thiourea) ligands and their application in Pd-catalyzed Heck and Suzuki reactions under aerobic conditions[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2006(5):1177_1184. |
| APA | Chen, W.,Li, R.,Han, B.,Li, BJ.,Chen, YC.,...&Chen, W, Sichuan Univ, W China Sch Pharm, Dept Med Chem, Chengdu 610041, Peoples R China..(2006).The design and synthesis of bis(thiourea) ligands and their application in Pd-catalyzed Heck and Suzuki reactions under aerobic conditions.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(5),1177_1184. |
| MLA | Chen, W,et al."The design and synthesis of bis(thiourea) ligands and their application in Pd-catalyzed Heck and Suzuki reactions under aerobic conditions".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .5(2006):1177_1184. |
入库方式： OAI收割
来源：成都生物研究所
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