Semi-permeable nanocapsules of konjac glucomannan-chitosan for enzyme immobilization
文献类型：期刊论文
| 作者 | Wang, R; Xia, B; Li, BJ; Peng, SL; Ding, LS; Zhang, S; Li, BJ, Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Peoples R China. |
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2008 |
| 卷号 | 364期号:1页码:102_107 |
| 关键词 | Carboxymethyl Konjac Glucomannan Chitosan Nanocapsule L-asparaginase Immobilization Semi-permeability |
| ISSN号 | 0378-5173 |
| 产权排序 | 1 |
| 英文摘要 | Carboxymethyl konjac glucomannan-chitosan (CKGM-CS) nanocapsules, spontaneously prepared under very mild conditions by electrostatic complexation, were used for immobilizing L-asparaginase. The matrix has semi-permeability to allow the Substrate and product to pass through and to keep L-asparaginase in the matrix to prevent leaking. The cell-like hydrogel matrix was prepared in aqueous system without organic solvents and reagents. The process of the preparation does not denature the enzyme and the activity of the immobilized and native enzyme is very similar. The activity, stability, and characters of the enzyme-loaded nanocapsules were studied. The results indicated the immobilized enzyme has better stability and activity in contrast to the native enzyme. These studies may supply a new material for the immobilization of pH and temperature-sensitive enzyme. (C) 2008 Elsevier B.V. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000261163100013 |
| 资助机构 | National Natural Science Foundation of China [30600148, 50703025] ; National Natural Science Foundation of China [30600148, 50703025] ; National Natural Science Foundation of China [30600148, 50703025] ; National Natural Science Foundation of China [30600148, 50703025] |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/18125]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 通讯作者 | Li, BJ, Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Wang, R,Xia, B,Li, BJ,et al. Semi-permeable nanocapsules of konjac glucomannan-chitosan for enzyme immobilization[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2008,364(1):102_107. |
| APA | Wang, R.,Xia, B.,Li, BJ.,Peng, SL.,Ding, LS.,...&Li, BJ, Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Peoples R China..(2008).Semi-permeable nanocapsules of konjac glucomannan-chitosan for enzyme immobilization.INTERNATIONAL JOURNAL OF PHARMACEUTICS,364(1),102_107. |
| MLA | Wang, R,et al."Semi-permeable nanocapsules of konjac glucomannan-chitosan for enzyme immobilization".INTERNATIONAL JOURNAL OF PHARMACEUTICS 364.1(2008):102_107. |
入库方式： OAI收割
来源：成都生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。