In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus
文献类型：期刊论文
| 作者 | Qin, L; Li, BG; Guan, JF; Zhang, GL; Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Peoples R China. |
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2009 |
| 卷号 | 23期号:4页码:309_318 |
| 关键词 | Helvolic Acid Synergistic Effect Multi-drug Resistance Staphylococcus Aureus |
| ISSN号 | 1478-6419 |
| 产权排序 | 1 |
| 英文摘要 | An agar plate method was established to screen synergistic antibacterial agents other than -lactamase inhibitors. By using this method, a strain Aspergillus sp136 was selected for further studies. From the metabolites of this strain, a synergistic antibacterial compound was isolated by bioautographic TLC assay-guided fractionation and identified as helvolic acid. The synergistic effect of helvolic acid to penicillin was about 3 times that of clavulanic acid to penicillin in agar diffusion assay on Bacillus cereus. In checkerboard studies, helvolic acid exhibited synergistic effects with erythromycin on all tested multi-drug resistant Staphylococcus aureus and with penicillin and tetracycline on some multi-drug resistant S. aureus. A pattern of enhanced killing was also found in time-kill studies on multi-drug resistant S. aureus. |
| 学科主题 | Chemistry, Applied ; Chemistry, Medicinal |
| 语种 | 英语 |
| WOS记录号 | WOS:000264337700001 |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/18249]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 通讯作者 | Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Qin, L,Li, BG,Guan, JF,et al. In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus[J]. NATURAL PRODUCT RESEARCH,2009,23(4):309_318. |
| APA | Qin, L,Li, BG,Guan, JF,Zhang, GL,&Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Peoples R China..(2009).In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus.NATURAL PRODUCT RESEARCH,23(4),309_318. |
| MLA | Qin, L,et al."In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus".NATURAL PRODUCT RESEARCH 23.4(2009):309_318. |
入库方式： OAI收割
来源：成都生物研究所
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