Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures
文献类型：期刊论文
| 作者 | Jiao, W; Dong, WW; Li, ZF; Deng, MC; Lu, RH; Lu, RH, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China. |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2009 |
| 卷号 | 17期号:13页码:4786_4792 |
| 关键词 | Euphorbia Lathyris Stereochemistry P-glycoprotein Mdr Lathyrane Diterpenes Jokinol Multidrug Resistance |
| ISSN号 | 0968-0896 |
| 产权排序 | 1 |
| 英文摘要 | Two lathyrane diterpenes (1-2) together with previous ones (3-6) were isolated from Euphorbia lathyris. The structures of 1 and 2 were established on the basis of extensive spectroscopic methods, including two-dimensional NMR techniques. Stereo configuration and conformation of 1 and 2 were analyzed by X-ray diffraction for the first time. The configuration of the unique isolathyrol diterpene 2 from the seeds of E. Lathyris, was rectified from S* to R* at C-5. All compounds were examined as modulators of multidrug resistance on MCF-7/ADM cell lines in vitro. Their structure-activity relationship was discussed from aspect of different skeletons. A class of potential P-gp inhibitors with five different types (jokinol, isolathyrol, epoxylathyrol, 7-hydroxylathyrol, lathyrol) was discovered. (C) 2009 Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000266822900056 |
| 资助机构 | Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/18253]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 通讯作者 | Lu, RH, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Jiao, W,Dong, WW,Li, ZF,et al. Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2009,17(13):4786_4792. |
| APA | Jiao, W,Dong, WW,Li, ZF,Deng, MC,Lu, RH,&Lu, RH, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China..(2009).Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures.BIOORGANIC & MEDICINAL CHEMISTRY,17(13),4786_4792. |
| MLA | Jiao, W,et al."Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures".BIOORGANIC & MEDICINAL CHEMISTRY 17.13(2009):4786_4792. |
入库方式： OAI收割
来源：成都生物研究所
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