New Eremophilane Sesquiterpenes from the Roots of Ligularia fischeri
文献类型：期刊论文
| 作者 | Deng, MC; Dong, WW; Jiao, W; Lu, RH; Lu, RH, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China. |
| 刊名 | HELVETICA CHIMICA ACTA
 |
| 出版日期 | 2009 |
| 卷号 | 92期号:3页码:495_501 |
| ISSN号 | 0018-019X |
| 产权排序 | 1 |
| 英文摘要 | New eremophilane sesquiterpenes, (3 beta,6 beta,8 alpha,10 beta)-3-acetyl-6,8,10-trihydroxyeremophil-7(11)-eno-12,8-lactone (1), (3 beta,6 beta,8 beta,10 beta)-3-acetyl-8,10-dihydroxy-6-(2-methyl-1-oxobutoxy) eremophil-7(11)-eno-12,8-lactone (2), (3 beta,6 beta,10 beta)- and (3 beta,6 beta,10 alpha)-3-acetyl-6,10-dihydroxyeremophila-7(11),8-dieno-12,8-lactone (3 and 4, resp.), and a dinoreremophilane derivative, (3aR,4R,5S,7aS)-2-acetyl-3a,4,5,6,7,7a-hexahydro-7a-hydroxy-1H-inden-5-y l acetate (5), were isolated from the roots of Ligularia fischeri. Their structures were elucidated by spectroscopic methods including 1D and 2D NMR spectra, and the structure of 1 was further confirmed by a single-crystal X-ray diffraction experiment. Among the isolated compounds, lactone 1 exhibited inhibitory activity towards PTP1B with an IC50 value of 1.34 mu M in vivo. The other compounds were inactive. |
| 学科主题 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000264843700008 |
| 资助机构 | Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Chinese Academy of Sciences |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/18257]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 通讯作者 | Lu, RH, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Deng, MC,Dong, WW,Jiao, W,et al. New Eremophilane Sesquiterpenes from the Roots of Ligularia fischeri[J]. HELVETICA CHIMICA ACTA,2009,92(3):495_501. |
| APA | Deng, MC,Dong, WW,Jiao, W,Lu, RH,&Lu, RH, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China..(2009).New Eremophilane Sesquiterpenes from the Roots of Ligularia fischeri.HELVETICA CHIMICA ACTA,92(3),495_501. |
| MLA | Deng, MC,et al."New Eremophilane Sesquiterpenes from the Roots of Ligularia fischeri".HELVETICA CHIMICA ACTA 92.3(2009):495_501. |
入库方式： OAI收割
来源：成都生物研究所
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