A New Triterpene and an Antiarrhythmic Liriodendrin from Pittosporum brevicalyx
文献类型：期刊论文
| 作者 | Feng, Chun; Li, Bo-Gang; Gao, Xiao-Ping; Qi, Hua-Yi; Zhang, Guo-Lin; Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China |
| 刊名 | ARCHIVES OF PHARMACAL RESEARCH
 |
| 出版日期 | 2010 |
| 卷号 | 33期号:12页码:1927-1932 |
| ISSN号 | 0253-6269 |
| 关键词 | Pittosporum Brevicalyx Liriodendrin Antiarrhythmic Cacl2-induced Arrhythmias |
| 产权排序 | 1 |
| 英文摘要 | A new triterpene, 21-O-senecioyl-R-1-barrigenol (1) and 13 known compounds were isolated from the ethanol extracts of the leaves and bark of Pittosporum brevicalyx (Oliv.) Gagnep. Their structures were elucidated based on spectral data. The antiarrhythmic action of one furofuran lignan, liriodendrin (2), was tested on a model of CaCl2-induced arrhythmia and compared with the effect of verapamil. The prophylactic administration of liriodendrin (2) was effective in prolonging latency of arrhythmia and reducing the occurrence of ventricular fibrillation from 75% to 25%. The overall mortality rate was significantly reduced by the prophylactic administration of liriodendrin from 87.5% to 25%. The antiarrhythmic effect of liriodendrin (5.0 mg/kg) was similar to that of verapamil (1.05 mg/kg). Thus, liriodendrin may be a potent suppressor of CaCl2-induced arrhythmias. |
| 学科主题 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000285794800007 |
| 资助机构 | Di-Ao Pharmaceutical Group in Chengdu ; Di-Ao Pharmaceutical Group in Chengdu ; Di-Ao Pharmaceutical Group in Chengdu ; Di-Ao Pharmaceutical Group in Chengdu |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/18359]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 通讯作者 | Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Chun,Li, Bo-Gang,Gao, Xiao-Ping,et al. A New Triterpene and an Antiarrhythmic Liriodendrin from Pittosporum brevicalyx[J]. ARCHIVES OF PHARMACAL RESEARCH,2010,33(12):1927-1932. |
| APA | Feng, Chun,Li, Bo-Gang,Gao, Xiao-Ping,Qi, Hua-Yi,Zhang, Guo-Lin,&Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China.(2010).A New Triterpene and an Antiarrhythmic Liriodendrin from Pittosporum brevicalyx.ARCHIVES OF PHARMACAL RESEARCH,33(12),1927-1932. |
| MLA | Feng, Chun,et al."A New Triterpene and an Antiarrhythmic Liriodendrin from Pittosporum brevicalyx".ARCHIVES OF PHARMACAL RESEARCH 33.12(2010):1927-1932. |
入库方式： OAI收割
来源：成都生物研究所
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