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Highly Diastereo- and Enantioselective Michael Additions of 3-Substituted Oxindoles to Maleimides Catalyzed by Chiral Bifunctional Thiourea-Tertiary Amine
文献类型：期刊论文
| 作者 | Liao, Yu-Hua; Liu, Xiong-Li; Wu, Zhi-Jun; Cun, Lin-Feng; Zhang, Xiao-Mei; Yuan, Wei-Cheng; Yuan, WC, Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2010 |
| 卷号 | 12期号:13页码:2896-2899 |
| ISSN号 | 1523-7060 |
| 产权排序 | 3 |
| 英文摘要 | A highly diastereo- and enantioselective Michael addition reaction with respect to prochiral 3-substituted oxindoles and maleimides by a chiral bifunctional thiourea tertiary amine catalyst was investigated for the first time. The corresponding adducts, containing a quaternary center at the C3-position of the oxindole as well as a vicinal tertiary center, were generally obtained in good to high yields (up to 92%) with high to excellent diastereo- (up to 99:1 dr) and enantioselectivities (up to 99% ee). |
| 学科主题 | Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000279070100002 |
| 资助机构 | NSFC [20802074]; National Basic Research Program of China (973 Program) [2010CB833300] ; NSFC [20802074]; National Basic Research Program of China (973 Program) [2010CB833300] ; NSFC [20802074]; National Basic Research Program of China (973 Program) [2010CB833300] ; NSFC [20802074]; National Basic Research Program of China (973 Program) [2010CB833300] |
| 公开日期 | 2011-07-08 |
| 源URL | [http://210.75.237.14/handle/351003/18399]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 通讯作者 | Yuan, WC, Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liao, Yu-Hua,Liu, Xiong-Li,Wu, Zhi-Jun,et al. Highly Diastereo- and Enantioselective Michael Additions of 3-Substituted Oxindoles to Maleimides Catalyzed by Chiral Bifunctional Thiourea-Tertiary Amine[J]. ORGANIC LETTERS,2010,12(13):2896-2899. |
| APA | Liao, Yu-Hua.,Liu, Xiong-Li.,Wu, Zhi-Jun.,Cun, Lin-Feng.,Zhang, Xiao-Mei.,...&Yuan, WC, Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China.(2010).Highly Diastereo- and Enantioselective Michael Additions of 3-Substituted Oxindoles to Maleimides Catalyzed by Chiral Bifunctional Thiourea-Tertiary Amine.ORGANIC LETTERS,12(13),2896-2899. |
| MLA | Liao, Yu-Hua,et al."Highly Diastereo- and Enantioselective Michael Additions of 3-Substituted Oxindoles to Maleimides Catalyzed by Chiral Bifunctional Thiourea-Tertiary Amine".ORGANIC LETTERS 12.13(2010):2896-2899. |
入库方式： OAI收割
来源：成都生物研究所
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