2-Phenylbenzo[b]furans: Synthesis and promoting activity on estrogen biosynthesis
文献类型：期刊论文
| 作者 | Zhang, GL (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China.; Pu, WC; Yuan, Y; Lu, DF; Wang, X; Liu, HW; Wang, C; Wang, F; Zhang, GL |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2016 |
| 卷号 | 26期号:22页码:5497-5500 |
| 关键词 | Estrogen Biosynthesis 2-phenylbenzo[b]Furan Decarboxylative Coupling Mcmurry Reaction |
| DOI | 10.1016/j.bmcl.2016.10.013 |
| 产权排序 | 1 |
| 文献子类 | Article |
| 英文摘要 | Estrogen biosynthesis is pivotal to many physiological processes of human. Aberrant estrogen level is closely related to a variety of diseases, including breast cancer and osteoporosis. Previously we found that 2phenylbenzo[b]furan glycosides could promote estrogen biosynthesis. To find high active 2-phenylbenzo [b]furans, fifty-four 2-phenylbenzo[b]furans were prepared via four strategies according to corresponding substrate scopes. Biological evaluation in HEK293A cells showed that some compounds exhibited promotive activity on estrogen biosynthesis. 2-(4-Chloropheny1)-7-methoxybenzo[b]furan possessed the highest activity with EC50 value of 14.68 mu M. Furthermore, these compounds did not affect aromatase expression in HEK292A cells, indicating that these 2-phenylbenzo[b]furans might enhance estrogen biosynthesis via directly allosteric regulation of aromatase or indirectly via posttranslational modification. (C) 2016 Elsevier Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| 资助机构 | National Natural Science Foundation of China [21372213, 21372214, 21172214, 21561142003] ; National Natural Science Foundation of China [21372213, 21372214, 21172214, 21561142003] ; Pillar Program of Science & Technology Department of Sichuan Province [2012SZ0219] ; Pillar Program of Science & Technology Department of Sichuan Province [2012SZ0219] ; Sichuan Youth Science & Technology Foundation [2014JQ0028] ; Sichuan Youth Science & Technology Foundation [2014JQ0028] ; Research Foundation of State General Administration of The People's Republic of China [2015IK180] ; Research Foundation of State General Administration of The People's Republic of China [2015IK180] ; National Natural Science Foundation of China [21372213, 21372214, 21172214, 21561142003] ; National Natural Science Foundation of China [21372213, 21372214, 21172214, 21561142003] ; Pillar Program of Science & Technology Department of Sichuan Province [2012SZ0219] ; Pillar Program of Science & Technology Department of Sichuan Province [2012SZ0219] ; Sichuan Youth Science & Technology Foundation [2014JQ0028] ; Sichuan Youth Science & Technology Foundation [2014JQ0028] ; Research Foundation of State General Administration of The People's Republic of China [2015IK180] ; Research Foundation of State General Administration of The People's Republic of China [2015IK180] |
| 源URL | [http://210.75.237.14/handle/351003/28171]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 通讯作者 | Zhang, GL (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Zhang, GL ,Pu, WC,Yuan, Y,et al. 2-Phenylbenzo[b]furans: Synthesis and promoting activity on estrogen biosynthesis[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(22):5497-5500. |
| APA | Zhang, GL .,Pu, WC.,Yuan, Y.,Lu, DF.,Wang, X.,...&Zhang, GL.(2016).2-Phenylbenzo[b]furans: Synthesis and promoting activity on estrogen biosynthesis.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(22),5497-5500. |
| MLA | Zhang, GL ,et al."2-Phenylbenzo[b]furans: Synthesis and promoting activity on estrogen biosynthesis".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.22(2016):5497-5500. |
入库方式： OAI收割
来源：成都生物研究所
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