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Cytotoxic triterpenoid saponins from Clematis tangutica

文献类型：期刊论文

作者Guo, DL; Da-Wa, ZM; Zhao, M; Zhou, Y; Ding, LS; Chen, L; Xia, B; Gu, YC; Xu, HX; Chen, XZ
刊名PHYTOCHEMISTRY
出版日期2016
卷号130页码:228-237
关键词Clematis Tangutica Ranunculaceae Triterpenoid Saponins Cytotoxic Activities
DOI10.1016/j.phytochem.2016.05.009
产权排序1
文献子类Article
英文摘要Eight previously undescribed oleanane-type triterpenoid saponins, clematangoticosides A-H, together with eight known saponins, were isolated from the whole plants of Clematis tangutica (Maxim.) Korsh. Their structures were elucidated by extensive spectroscopic analysis, in combination with chemical methods (acid hydrolysis and mild alkaline hydrolysis). Clematangoticosides D-G were found to be unusual 23, 28-bidesmosidic glycosides. The cytotoxic activities of all of the isolated saponins were evaluated against the four human cancer cell lines SGC-7901, HepG2, HL-60 and U251MG. Clematoside S, sapindoside B, kalopanax saponin A, and koelreuteria saponin A exhibited cytotoxicity against all of the test cancer cell lines with 1050 values in the range of 1.88-27.20 mu M, while clematangoticoside D and F showed selective cytotoxicity against SGC-7901 with IC50 values of 24.22 and 2135 mu M, respectively. (C) 2016 Elsevier Ltd. All rights reserved.
学科主题Biochemistry & Molecular Biology ; Plant Sciences
资助项目中国科学院山地生态恢复与生物资源利用重点实验室
语种英语
资助机构National Natural Sciences Foundation of China [21402157, 21402187, 21572219, 21572221] ; National Natural Sciences Foundation of China [21402157, 21402187, 21572219, 21572221] ; Syngenta Postgraduate Fellowship ; Syngenta Postgraduate Fellowship ; National Natural Sciences Foundation of China [21402157, 21402187, 21572219, 21572221] ; National Natural Sciences Foundation of China [21402157, 21402187, 21572219, 21572221] ; Syngenta Postgraduate Fellowship ; Syngenta Postgraduate Fellowship
源URL[http://210.75.237.14/handle/351003/28177]  
专题成都生物研究所_天然产物研究
通讯作者Ding, LS; Zhou, Y (reprint author), Chinese Acad Sci, Key Lab Mt Ecol Restorat & Bioresource Utilizat, Chengdu Inst Biol, Chengdu 610041, Peoples R China.
推荐引用方式
GB/T 7714		 Guo, DL,Da-Wa, ZM,Zhao, M,et al. Cytotoxic triterpenoid saponins from Clematis tangutica[J]. PHYTOCHEMISTRY,2016,130:228-237.
APA Guo, DL.,Da-Wa, ZM.,Zhao, M.,Zhou, Y.,Ding, LS.,...&Zhou, Y .(2016).Cytotoxic triterpenoid saponins from Clematis tangutica.PHYTOCHEMISTRY,130,228-237.
MLA Guo, DL,et al."Cytotoxic triterpenoid saponins from Clematis tangutica".PHYTOCHEMISTRY 130(2016):228-237.

入库方式： OAI收割

来源：成都生物研究所

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