Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells
文献类型：期刊论文
| 作者 | Wu, JS; Zhang, H; Hu, BY; Yang, LJ; Wang, P; Wang, F; Meng, XL; Meng, XL (reprint author), Chengdu Univ Tradit Chinese Med, Chengdu 611137, Peoples R China.; Wang, F (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China. |
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 780页码:106-114 |
| 关键词 | Coptisine Coptis Chinensis Inflammation Nitric Oxide Macrophage |
| DOI | 10.1016/j.ejphar.2016.03.037 |
| 产权排序 | 2 |
| 文献子类 | Article |
| 英文摘要 | Coptis chinensis has been used for the treatment of inflammatory diseases in China and other Asian countries for centuries. However, the chemical constituents and mechanism underlying the anti-inflammatory activity of this medicinal plant are poorly understood. Here, coptisine, the main constituent of C. chinensis, was shown to potently inhibit the production of nitric oxide (NO) by suppressing the protein and mRNA expressions of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)stimulated RAW 264.7 macrophages. Coptisine also inhibited the production of the pro-inflammatory cytokines interleukin-1I3 (IL-113) and interleukin-6 (IL-6) by suppressing expression of cytokine mRNA. Coptisine suppressed the degradation of inhibitor of nuclear factor kappa B alpha (I kappa B alpha) and phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and phosphoinositide 3-kinase/Alt (PI3K/Akt). Coptisine had no effect on the expression of toll-like receptor 4 (TLR-4) and myeloid differentiation factor 88 (MyD88) as well as LPS binding to TLR-4. Coptisine also inhibited carrageenan-elicited rat paw edema and reduced the release of TNF-oc and NO in rat inflamed tissue. These results suggest that coptisine inhibits LPS-stimulated inflammation by blocking nuclear factor-kappa B, MAPK, and PI3K/Akt activation in macrophages, and can be used as an agent for the prevention and treatment of inflammatory diseases. (C) 2016 Elsevier B.V. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 资助机构 | National Natural Science Foundation of China [81073118, 81274111, 81473419] ; National Natural Science Foundation of China [81073118, 81274111, 81473419] ; Sichuan Youth Science & Technology Foundation [2014JQ0028] ; Sichuan Youth Science & Technology Foundation [2014JQ0028] ; West Light Foundation of Chinese Academy of Sciences ; West Light Foundation of Chinese Academy of Sciences ; National Natural Science Foundation of China [81073118, 81274111, 81473419] ; National Natural Science Foundation of China [81073118, 81274111, 81473419] ; Sichuan Youth Science & Technology Foundation [2014JQ0028] ; Sichuan Youth Science & Technology Foundation [2014JQ0028] ; West Light Foundation of Chinese Academy of Sciences ; West Light Foundation of Chinese Academy of Sciences |
| 源URL | [http://210.75.237.14/handle/351003/28191]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 通讯作者 | Meng, XL (reprint author), Chengdu Univ Tradit Chinese Med, Chengdu 611137, Peoples R China.; Wang, F (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Wu, JS,Zhang, H,Hu, BY,et al. Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2016,780:106-114. |
| APA | Wu, JS.,Zhang, H.,Hu, BY.,Yang, LJ.,Wang, P.,...&Wang, F .(2016).Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.EUROPEAN JOURNAL OF PHARMACOLOGY,780,106-114. |
| MLA | Wu, JS,et al."Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells".EUROPEAN JOURNAL OF PHARMACOLOGY 780(2016):106-114. |
入库方式： OAI收割
来源：成都生物研究所
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