Four new phorbol diesters from Croton tiglium and their cytotoxic activities
文献类型:期刊论文
作者 | Wang, L; Yu, K; Li, F; Wang, MK; Wang, MK (reprint author), Chengdu Univ, Sch Pharm & Bioengn, Chengdu 610106, Peoples R China.; Zhang, XL; Khan, AA |
刊名 | PHYTOCHEMISTRY LETTERS
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出版日期 | 2016 |
卷号 | 16页码:82-86 |
关键词 | Croton Tiglium 4-deoxy-4b-phorbol Diesters Cytotoxic Activity |
DOI | 10.1016/j.phytol.2016.03.008 |
产权排序 | 1 |
文献子类 | Article |
英文摘要 | Phytochemical investigation of the seeds of Croton tiglium resulted in the isolation and structure elucidation of four new 4-deoxy-4 beta-phorbol diesters (1-4) named as 12-O-tiglylphorbol-4-deoxy-4 beta-phorbol-13-acetate (1), 12-O-tiglylphorbol-4-deoxy-4 beta-phorbol-13-hexadecanoate (2), 13-O-acetylphorbol-4-deoxy-4 beta-phorbol-20-oleate (3) and 13-O-acetylphorbol-4-deoxy-4 beta-phorbol-20-linoleate (4), respectively. The structures of the new compounds were established by 1D, 2D-NMR and HR-ESI-MS spectroscopic data and chemical degradation experiments. The cytotoxic activities of compounds 1-4 were evaluated against hepatic tumor cell lines (SNU387 and SNU398). Among these compounds, compound 4 exhibited the most potent activity against the SNU387 with IC50 value of 0.71 mu M. (C) 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. |
学科主题 | Plant Sciences ; Pharmacology & Pharmacy |
资助项目 | 中国科学院山地生态恢复与生物资源利用重点实验室 |
语种 | 英语 |
资助机构 | Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; National Natural Science Foundation of China [21561142003] ; National Natural Science Foundation of China [21561142003] ; Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; National Natural Science Foundation of China [21561142003] ; National Natural Science Foundation of China [21561142003] |
源URL | [http://210.75.237.14/handle/351003/28192] ![]() |
专题 | 成都生物研究所_天然产物研究 |
通讯作者 | Li, F; Wang, MK (reprint author), Chengdu Univ, Sch Pharm & Bioengn, Chengdu 610106, Peoples R China. |
推荐引用方式 GB/T 7714 | Wang, L,Yu, K,Li, F,et al. Four new phorbol diesters from Croton tiglium and their cytotoxic activities[J]. PHYTOCHEMISTRY LETTERS,2016,16:82-86. |
APA | Wang, L.,Yu, K.,Li, F.,Wang, MK.,Wang, MK .,...&Khan, AA.(2016).Four new phorbol diesters from Croton tiglium and their cytotoxic activities.PHYTOCHEMISTRY LETTERS,16,82-86. |
MLA | Wang, L,et al."Four new phorbol diesters from Croton tiglium and their cytotoxic activities".PHYTOCHEMISTRY LETTERS 16(2016):82-86. |
入库方式: OAI收割
来源:成都生物研究所
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