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Four new phorbol diesters from Croton tiglium and their cytotoxic activities

文献类型:期刊论文

作者Wang, L; Yu, K; Li, F; Wang, MK; Wang, MK (reprint author), Chengdu Univ, Sch Pharm & Bioengn, Chengdu 610106, Peoples R China.; Zhang, XL; Khan, AA
刊名PHYTOCHEMISTRY LETTERS
出版日期2016
卷号16页码:82-86
关键词Croton Tiglium 4-deoxy-4b-phorbol Diesters Cytotoxic Activity
DOI10.1016/j.phytol.2016.03.008
产权排序1
文献子类Article
英文摘要Phytochemical investigation of the seeds of Croton tiglium resulted in the isolation and structure elucidation of four new 4-deoxy-4 beta-phorbol diesters (1-4) named as 12-O-tiglylphorbol-4-deoxy-4 beta-phorbol-13-acetate (1), 12-O-tiglylphorbol-4-deoxy-4 beta-phorbol-13-hexadecanoate (2), 13-O-acetylphorbol-4-deoxy-4 beta-phorbol-20-oleate (3) and 13-O-acetylphorbol-4-deoxy-4 beta-phorbol-20-linoleate (4), respectively. The structures of the new compounds were established by 1D, 2D-NMR and HR-ESI-MS spectroscopic data and chemical degradation experiments. The cytotoxic activities of compounds 1-4 were evaluated against hepatic tumor cell lines (SNU387 and SNU398). Among these compounds, compound 4 exhibited the most potent activity against the SNU387 with IC50 value of 0.71 mu M. (C) 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
学科主题Plant Sciences ; Pharmacology & Pharmacy
资助项目中国科学院山地生态恢复与生物资源利用重点实验室
语种英语
资助机构Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; National Natural Science Foundation of China [21561142003] ; National Natural Science Foundation of China [21561142003] ; Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; Key Research Program of the Chinese Academy of Sciences [KSZD-EW-Z-004] ; National Natural Science Foundation of China [21561142003] ; National Natural Science Foundation of China [21561142003]
源URL[http://210.75.237.14/handle/351003/28192]  
专题成都生物研究所_天然产物研究
通讯作者Li, F; Wang, MK (reprint author), Chengdu Univ, Sch Pharm & Bioengn, Chengdu 610106, Peoples R China.
推荐引用方式
GB/T 7714
Wang, L,Yu, K,Li, F,et al. Four new phorbol diesters from Croton tiglium and their cytotoxic activities[J]. PHYTOCHEMISTRY LETTERS,2016,16:82-86.
APA Wang, L.,Yu, K.,Li, F.,Wang, MK.,Wang, MK .,...&Khan, AA.(2016).Four new phorbol diesters from Croton tiglium and their cytotoxic activities.PHYTOCHEMISTRY LETTERS,16,82-86.
MLA Wang, L,et al."Four new phorbol diesters from Croton tiglium and their cytotoxic activities".PHYTOCHEMISTRY LETTERS 16(2016):82-86.

入库方式: OAI收割

来源:成都生物研究所

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