中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Bioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata

文献类型:期刊论文

作者Tang, L; Yin, L; Lu, QX; Tan, SC; Ding, LS; Guo, YR; Chen, F; Tang, L (reprint author), Sichuan Univ, Coll Life Sci, Key Lab Bioresources & Ecoenvironm, Minist Educ, 24 South Sect 1,Yihuan Rd, Chengdu, Peoples R China.
刊名CHEMISTRY CENTRAL JOURNAL
出版日期2016
卷号10页码:27(1-8)
关键词Scrophulariaceae Veronica Ciliata Antioxidant Anti-hepatocarcinoma Iridoid Glycosides Bioactivity-guided Screening
DOI10.1186/s13065-016-0172-1
产权排序3
文献子类Article
英文摘要Background: Veronica ciliata Fisch., widely distributed in western China, has been traditionally used in Tibetan Medicine as a treatment for hepatitis, cholecystitis, rheumatism, and urticaria. However, V. ciliata Fisch. has not been subjected to detailed chemical constitution analysis and the bioactive studies were restricted to its crude extracts. It is necessary to investigate the active chemical components of these extracts and identify their biological effects. Results: Four iridoid glycosides, (veronicoside, cataposide, amphicoside, and verminoside) were isolated from the ethyl acetate fraction. Among these compounds, veronicoside and verminoside were isolated for the first time from this plant. These compounds exhibited strong antioxidant activity and inhibitory activity on HepG2 cell proliferation. The antioxidant activity of verminoside was equal to Vc. Cataposide, amphicoside and verminoside had stronger anti-hepatocarcinoma activity than 5-fluorouracil. Conclusions: Four iridoid glycosides, (veronicoside, cataposide, amphicoside and verminoside) were isolated from the extract of V. ciliata Fisch. using bioassay-guided screening. Among these compounds, veronicoside and verminoside were isolated for the first time from this plant. The above results indicated that these compounds were the active chemical components responsible for the antioxidant and anti-hepatocarcinoma properties of V. ciliata Fisch. The underlying mechanism of their bioactivity is worthy of further investigation.
学科主题Chemistry
资助项目中国科学院山地生态恢复与生物资源利用重点实验室
语种英语
资助机构National Natural Science Foundation of China [31570351] ; National Natural Science Foundation of China [31570351] ; National Natural Science Foundation of China [31570351] ; National Natural Science Foundation of China [31570351]
源URL[http://210.75.237.14/handle/351003/28195]  
专题成都生物研究所_天然产物研究
通讯作者Tang, L (reprint author), Sichuan Univ, Coll Life Sci, Key Lab Bioresources & Ecoenvironm, Minist Educ, 24 South Sect 1,Yihuan Rd, Chengdu, Peoples R China.
推荐引用方式
GB/T 7714
Tang, L,Yin, L,Lu, QX,et al. Bioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata[J]. CHEMISTRY CENTRAL JOURNAL,2016,10:27(1-8).
APA Tang, L.,Yin, L.,Lu, QX.,Tan, SC.,Ding, LS.,...&Tang, L .(2016).Bioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata.CHEMISTRY CENTRAL JOURNAL,10,27(1-8).
MLA Tang, L,et al."Bioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata".CHEMISTRY CENTRAL JOURNAL 10(2016):27(1-8).

入库方式: OAI收割

来源:成都生物研究所

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