Enantioselective synthesis of chiral alpha,beta-unsaturated gamma-substituted butyrolactams by organocatalyzed direct asymmetric vinylogous Michael addition of alpha,beta-unsaturated gamma-butyrolactam to 2-enoylpyridines
文献类型：期刊论文
| 作者 | You, Y; Wu, ZJ; Wang, ZH; Yuan, WC (reprint author), Chinese Acad Sci, Chengdu Inst Organ Chem, Natl Engn Res Ctr Chiral Drugs, Chengdu 610041, Peoples R China.; Yuan, WC; Zhang, XM; Xu, XY; Yue, DF |
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2016 |
| 卷号 | 14期号:27页码:6568-6576 |
| DOI | 10.1039/c6ob01191h |
| 产权排序 | 2 |
| 文献子类 | Article |
| 英文摘要 | An organocatalyzed direct asymmetric vinylogous Michael addition reaction of alpha,beta-unsaturated gamma-butyrolactam to 2-enoylpyridines has been developed with a chiral bifunctional amine-squaramide as the catalyst. This approach provides easy access to a series of optically active alpha,beta-unsaturated gamma-substituted butyrolactams in high yields (up to 99%) with excellent diastereoselectivities (up to >99 : 1) and enantio-selectivities (up to >99% ee). |
| 学科主题 | Chemistry |
| 语种 | 英语 |
| 资助机构 | National Natural Science Foundation of China [21372217, 21572223, 21572224] ; National Natural Science Foundation of China [21372217, 21572223, 21572224] ; Sichuan Youth Science and Technology Foundation [2013JQ0021, 2015JQO041] ; Sichuan Youth Science and Technology Foundation [2013JQ0021, 2015JQO041] ; National Natural Science Foundation of China [21372217, 21572223, 21572224] ; National Natural Science Foundation of China [21372217, 21572223, 21572224] ; Sichuan Youth Science and Technology Foundation [2013JQ0021, 2015JQO041] ; Sichuan Youth Science and Technology Foundation [2013JQ0021, 2015JQO041] |
| 源URL | [http://210.75.237.14/handle/351003/28218]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 通讯作者 | Yuan, WC (reprint author), Chinese Acad Sci, Chengdu Inst Organ Chem, Natl Engn Res Ctr Chiral Drugs, Chengdu 610041, Peoples R China.; Xu, XY |
| 推荐引用方式 GB/T 7714 | You, Y,Wu, ZJ,Wang, ZH,et al. Enantioselective synthesis of chiral alpha,beta-unsaturated gamma-substituted butyrolactams by organocatalyzed direct asymmetric vinylogous Michael addition of alpha,beta-unsaturated gamma-butyrolactam to 2-enoylpyridines[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2016,14(27):6568-6576. |
| APA | You, Y.,Wu, ZJ.,Wang, ZH.,Yuan, WC .,Yuan, WC.,...&Yue, DF.(2016).Enantioselective synthesis of chiral alpha,beta-unsaturated gamma-substituted butyrolactams by organocatalyzed direct asymmetric vinylogous Michael addition of alpha,beta-unsaturated gamma-butyrolactam to 2-enoylpyridines.ORGANIC & BIOMOLECULAR CHEMISTRY,14(27),6568-6576. |
| MLA | You, Y,et al."Enantioselective synthesis of chiral alpha,beta-unsaturated gamma-substituted butyrolactams by organocatalyzed direct asymmetric vinylogous Michael addition of alpha,beta-unsaturated gamma-butyrolactam to 2-enoylpyridines".ORGANIC & BIOMOLECULAR CHEMISTRY 14.27(2016):6568-6576. |
入库方式： OAI收割
来源：成都生物研究所
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