Synthesis of 5-subsituted flavonols via the Algar-Flynn-Oyamada (AFO) reaction: The mechanistic implication
文献类型：期刊论文
| 作者 | Zhou, Q; Shen, XY; Xiong, W; Pu, WC; Zhang, W; Zhang, GL; Wang, C; Wang, C (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China. |
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2017 |
| 卷号 | 73期号:32页码:4822-4829 |
| 关键词 | Flavonol Synthesis Afo Mechanism |
| DOI | 10.1016/j.tet.2017.06.064 |
| 产权排序 | 1 |
| 文献子类 | Article |
| 英文摘要 | Herein, we report a synthetic method with improved selectivity for 5-substituted flavonols via the Algar-Flynn-Oyamada reaction (AFO), by using of sodium carbonate/hydrogen peroxide A series of 5 substituted flavonols was obtained with moderate to high yields. The mechanism of the AFO reaction was elucidated. LCMS analysis and in situ H-1 NMR analysis indicated that the epoxide was involved in the transformation from chalcone to flavonol and/or aurone under alkaline base/peroxide conditions. (C) 2017 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry |
| 资助项目 | Pu, Wenchen/E-9537-2018 ; Zhang, Wei/H-2082-2012 |
| 语种 | 英语 |
| 资助机构 | Financial supports from the National Natural Science Foundation of China (No. 21172214, 21561142003), Science and Technology Department of Sichuan Province (2016JY0034), Youth Innovation Promotion Association, CAS (2015316), are gratefully acknowledged. ; National Natural Science Foundation of China [21172214, 21561142003] ; Financial supports from the National Natural Science Foundation of China (No. 21172214, 21561142003), Science and Technology Department of Sichuan Province (2016JY0034), Youth Innovation Promotion Association, CAS (2015316), are gratefully acknowledged. ; National Natural Science Foundation of China [21172214, 21561142003] ; Science and Technology Department of Sichuan Province [2016JY0034] ; Science and Technology Department of Sichuan Province [2016JY0034] ; Youth Innovation Promotion Association, CAS [2015316] ; Youth Innovation Promotion Association, CAS [2015316] ; Financial supports from the National Natural Science Foundation of China (No. 21172214, 21561142003), Science and Technology Department of Sichuan Province (2016JY0034), Youth Innovation Promotion Association, CAS (2015316), are gratefully acknowledged. ; National Natural Science Foundation of China [21172214, 21561142003] ; Financial supports from the National Natural Science Foundation of China (No. 21172214, 21561142003), Science and Technology Department of Sichuan Province (2016JY0034), Youth Innovation Promotion Association, CAS (2015316), are gratefully acknowledged. ; National Natural Science Foundation of China [21172214, 21561142003] ; Science and Technology Department of Sichuan Province [2016JY0034] ; Science and Technology Department of Sichuan Province [2016JY0034] ; Youth Innovation Promotion Association, CAS [2015316] ; Youth Innovation Promotion Association, CAS [2015316] |
| 源URL | [http://210.75.237.14/handle/351003/29219]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 通讯作者 | Zhang, GL; Wang, C (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Zhou, Q,Shen, XY,Xiong, W,et al. Synthesis of 5-subsituted flavonols via the Algar-Flynn-Oyamada (AFO) reaction: The mechanistic implication[J]. TETRAHEDRON,2017,73(32):4822-4829. |
| APA | Zhou, Q.,Shen, XY.,Xiong, W.,Pu, WC.,Zhang, W.,...&Wang, C .(2017).Synthesis of 5-subsituted flavonols via the Algar-Flynn-Oyamada (AFO) reaction: The mechanistic implication.TETRAHEDRON,73(32),4822-4829. |
| MLA | Zhou, Q,et al."Synthesis of 5-subsituted flavonols via the Algar-Flynn-Oyamada (AFO) reaction: The mechanistic implication".TETRAHEDRON 73.32(2017):4822-4829. |
入库方式： OAI收割
来源：成都生物研究所
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