Astragalosidic Acid: A New Water-Soluble Derivative of Astragaloside IV Prepared Using Remarkably Simple TEMPO-Mediated Oxidation
文献类型：期刊论文
| 作者 | Qing, LS; Peng, SL; Liang, J; Ding, LS; Ding, LS (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China. |
| 刊名 | MOLECULES
 |
| 出版日期 | 2017 |
| 卷号 | 22期号:8页码:1-7 |
| 关键词 | Astragalosidic Acid Astragaloside Iv Water-soluble Derivative Tempo-mediated Oxidation Cardioprotective Activity |
| DOI | 10.3390/molecules22081275 |
| 产权排序 | 1 |
| 文献子类 | Article |
| 英文摘要 | There is an urgent need for a water-soluble derivative of astragaloside IV for drug R&D. In the present study, a remarkably simple method for the preparation of such a water-soluble derivative of astragaloside IV has been developed. This protocol involves oxidative 2,2,6,6-tetramethylpiperidine-1-oxyl free radical (TEMPO)-mediated transformation of astragaloside IV to its carboxylic acid derivative, which is a new compound named astragalosidic acid. The structure of astragalosidic acid was elucidated by means of spectroscopic analysis. Its cardioprotective activity was investigated using an in vitro model of cardiomyocyte damage induced by hypoxia/reoxygenation in H9c2 cells. The oxidative TEMPO-mediated transformation proposed in the present study could be applied to other natural saponins, offering an effective and convenient way to develop a new compound with greatly improved structure-based druggability. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| 资助机构 | This work was supported by National Natural Science Foundation of China (No. 21572219) and Bureau of Science and Technology for Development, Chinese Academy of Sciences (Project for the discovery, evaluation and transformation of active natural compounds. No. ZSTH-005). ; National Natural Science Foundation of China [21572219] ; This work was supported by National Natural Science Foundation of China (No. 21572219) and Bureau of Science and Technology for Development, Chinese Academy of Sciences (Project for the discovery, evaluation and transformation of active natural compounds. No. ZSTH-005). ; National Natural Science Foundation of China [21572219] ; Bureau of Science and Technology for Development, Chinese Academy of Sciences [ZSTH-005] ; Bureau of Science and Technology for Development, Chinese Academy of Sciences [ZSTH-005] ; This work was supported by National Natural Science Foundation of China (No. 21572219) and Bureau of Science and Technology for Development, Chinese Academy of Sciences (Project for the discovery, evaluation and transformation of active natural compounds. No. ZSTH-005). ; National Natural Science Foundation of China [21572219] ; This work was supported by National Natural Science Foundation of China (No. 21572219) and Bureau of Science and Technology for Development, Chinese Academy of Sciences (Project for the discovery, evaluation and transformation of active natural compounds. No. ZSTH-005). ; National Natural Science Foundation of China [21572219] ; Bureau of Science and Technology for Development, Chinese Academy of Sciences [ZSTH-005] ; Bureau of Science and Technology for Development, Chinese Academy of Sciences [ZSTH-005] |
| 源URL | [http://210.75.237.14/handle/351003/29220]  |
| 专题 | 成都生物研究所_天然产物研究 |
| 通讯作者 | Ding, LS (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Qing, LS,Peng, SL,Liang, J,et al. Astragalosidic Acid: A New Water-Soluble Derivative of Astragaloside IV Prepared Using Remarkably Simple TEMPO-Mediated Oxidation[J]. MOLECULES,2017,22(8):1-7. |
| APA | Qing, LS,Peng, SL,Liang, J,Ding, LS,&Ding, LS .(2017).Astragalosidic Acid: A New Water-Soluble Derivative of Astragaloside IV Prepared Using Remarkably Simple TEMPO-Mediated Oxidation.MOLECULES,22(8),1-7. |
| MLA | Qing, LS,et al."Astragalosidic Acid: A New Water-Soluble Derivative of Astragaloside IV Prepared Using Remarkably Simple TEMPO-Mediated Oxidation".MOLECULES 22.8(2017):1-7. |
入库方式： OAI收割
来源：成都生物研究所
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