Monitoring Fluorinated Dendrimer-Based Self-Assembled Drug-Delivery Systems with F-19 Magnetic Resonance
文献类型：期刊论文
| 作者 | Jiang, Zhong-Xing1,2; Bo, Shaowei2; Yuan, Yaping3; Liu, Xin2; Chen, Shizhen3; Zhou, Xin3; Yang, Zhigang2; Li, Yu2 |
| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2017-08-17 |
| 期号 | 30页码:4461-4468 |
| 关键词 | Self-assembly Drug Delivery Fluorine Dendrimers Stacking Interactions |
| DOI | 10.1002/ejoc.201700566 |
| 文献子类 | Article |
| 英文摘要 | Monitoring a drug-delivery system with an imaging modality is of great importance for detailed understanding of drug-delivery processes and for achieving optimal therapeutic effects. Here, novel fluorinated self-assembled dendrimers with a single F-19 NMR signal were conveniently synthesized on multigram scales, and F-19 magnetic resonance, including spectroscopy (F-19 NMR) and imaging (F-19 MRI), was used to monitor the fluorinated dendrimer-based self-assembled drug-delivery systems. It was found that F-19 NMR and F-19 MRI were convenient and sensitive tools to monitor the self-assembly and drug-loading processes and to detect weak interactions between the drug and the drug-delivery vehicle because changes in the self-assembly profile sensitively induced corresponding F-19 magnetic resonance responses. |
| WOS关键词 | NMR-SPECTROSCOPY ; IMAGING AGENT ; MRI ; DESIGN ; TRANSITIONS ; PERFORMANCE ; AMPHIPHILE ; LIGANDS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000407822200015 |
| 资助机构 | National Key Research and Development Program of China(2016YFC1304704) ; National Key Research and Development Program of China(2016YFC1304704) ; National Natural Science Foundation of China(21372181 ; National Natural Science Foundation of China(21372181 ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials (Donghua University) ; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials (Donghua University) ; 21402144 ; 21402144 ; 21572168) ; 21572168) ; National Key Research and Development Program of China(2016YFC1304704) ; National Key Research and Development Program of China(2016YFC1304704) ; National Natural Science Foundation of China(21372181 ; National Natural Science Foundation of China(21372181 ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials (Donghua University) ; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials (Donghua University) ; 21402144 ; 21402144 ; 21572168) ; 21572168) |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/11316]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Donghua Univ, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China 2.Wuhan Univ, Sch Pharmaceut Sci, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Zhong-Xing,Bo, Shaowei,Yuan, Yaping,et al. Monitoring Fluorinated Dendrimer-Based Self-Assembled Drug-Delivery Systems with F-19 Magnetic Resonance[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2017(30):4461-4468. |
| APA | Jiang, Zhong-Xing.,Bo, Shaowei.,Yuan, Yaping.,Liu, Xin.,Chen, Shizhen.,...&Li, Yu.(2017).Monitoring Fluorinated Dendrimer-Based Self-Assembled Drug-Delivery Systems with F-19 Magnetic Resonance.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(30),4461-4468. |
| MLA | Jiang, Zhong-Xing,et al."Monitoring Fluorinated Dendrimer-Based Self-Assembled Drug-Delivery Systems with F-19 Magnetic Resonance".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .30(2017):4461-4468. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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