Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation
文献类型：期刊论文
| 作者 | Li, Sha2; Liu, Lianhua2; Chen, Shizhen2; Yang, Yuqi2; Zhou, Xin2; Liu, Maili2; Bouchard, Louis-S.1,3; Zhang, Zhiying2; Li, Haidong2; Zhao, Xiuchao2 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017-07-19 |
| 卷号 | 9期号:28页码:23400-23408 |
| 关键词 | Photodynamic Therapy Biological Redox Therapy Photothermal Therapy Graphene Quantum Dots Dual-modality Imaging |
| DOI | 10.1021/acsami.7b05463 |
| 文献子类 | Article |
| 英文摘要 | Currently, the potential of cancer therapy is compromised by a variety of problems related to tumor specificity, drug access, and limited efficacy. We report a novel approach to improve the effectiveness of cancer treatment utilizing a light-responsive nanoconstruct. Effectiveness is increased by enhancing drug absorption through heating and the production of free radicals. Treatment specificity is increased through chemical targeting of the nanoconstruct and localization of light delivery to the tumor. When reaching the tumor, magnetic resonance imaging is enhanced and near-infrared fluorescence is activated upon drug release, making it possible to visualize the localized treatment at both the tissue and cellular levels. This dual-modality imaging nanoconstruct enables the synergistic treatment and observable evaluation of solid tumors with dramatically improved efficacy, giving rise to a promising new approach for cancer therapy and evaluation. |
| WOS关键词 | GRAPHENE QUANTUM DOTS ; PHOTODYNAMIC THERAPY ; ANTITUMOR IMMUNITY ; NANOPARTICLES ; SENSITIVITY ; GADOLINIUM ; AGENT ; CELLS ; DRUG |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000406172700014 |
| 资助机构 | National Natural Science Foundation of China(21605158 ; National Natural Science Foundation of China(21605158 ; National Program for Special Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; National Program for Special Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; 21575157 ; 21575157 ; 81227902) ; 81227902) ; National Natural Science Foundation of China(21605158 ; National Natural Science Foundation of China(21605158 ; National Program for Special Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; National Program for Special Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; 21575157 ; 21575157 ; 81227902) ; 81227902) |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/11320]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Univ Calif Los Angeles, Dept Bioengn, Jonsson Comprehens Canc Ctr, Calif NanoSyst Inst,Mol Biol Inst, Los Angeles, CA 90095 USA 2.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Peoples R China 3.Univ Calif Los Angeles, Dept Chem & Biochem, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA |
| 推荐引用方式 GB/T 7714 | Li, Sha,Liu, Lianhua,Chen, Shizhen,et al. Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(28):23400-23408. |
| APA | Li, Sha.,Liu, Lianhua.,Chen, Shizhen.,Yang, Yuqi.,Zhou, Xin.,...&Zen, Qingbin.(2017).Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation.ACS APPLIED MATERIALS & INTERFACES,9(28),23400-23408. |
| MLA | Li, Sha,et al."Increasing Cancer Therapy Efficiency through Targeting and Localized Light Activation".ACS APPLIED MATERIALS & INTERFACES 9.28(2017):23400-23408. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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