WS2 and MoS2 biosensing platforms using peptides as probe biomolecules
文献类型：期刊论文
| 作者 | Fu, Caihong2; Fan, Jun2; Sun, Xiuxia2; Xiao, Jianxi1,2; Wang, Jie1; Zhao, Sha2; Yao, Linyan2 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017-08-31 |
| 卷号 | 7 |
| DOI | 10.1038/s41598-017-10221-4 |
| 文献子类 | Article |
| 英文摘要 | Biosensors based on the two-dimensional layered nanomaterials transition metal dichalcogenides such as WS2 and MoS2 have shown broad applications, while they largely rely on the utilization of single stranded DNA as probe biomolecules. Herein we have constructed novel WS2- and MoS2-based biosensing platforms using peptides as probe biomolecules. We have revealed for the first time that the WS2 and MoS2 nanosheets display a distinct adsorption for Arg amino acid and particularly, Arg-rich peptdies. We have demonstrated that the WS2 and MoS2 dramatically quench the fluorescence of our constructed Arg-rich probe peptide, while the hybridization of the probe peptide with its target collagen sequence leads to the fluorescence recovery. The WS2-based platform provides a sensitive fluorescence-enhanced assay that is highly specific to the target collagen peptide with little interferences from other proteins. This assay can be applied for quantitative detection of collagen biomarkers in complex biological fluids. The successful development of WS2- and MoS2-based biosensors using non-ssDNA probes opens great opportunities for the construction of novel multifunctional biosensing platforms, which may have great potential in a wide range of biomedical field. |
| WOS关键词 | GRAPHENE OXIDE ; FLUORESCENT BIOSENSOR ; MONOCLONAL-ANTIBODIES ; POLYMER NANOCOMPOSITES ; SENSING APPLICATIONS ; CARBON NANOTUBES ; TRIPLE-HELIX ; II COLLAGEN ; NANOSHEETS ; DNA |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000408781200149 |
| 资助机构 | National Natural Science Foundation of China(21305056) ; National Natural Science Foundation of China(21305056) ; Fundamental Research Funds for the Central Universities(lzujbky-2016-k10) ; Fundamental Research Funds for the Central Universities(lzujbky-2016-k10) ; open fund of State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics(T151402) ; open fund of State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics(T151402) ; National Natural Science Foundation of China(21305056) ; National Natural Science Foundation of China(21305056) ; Fundamental Research Funds for the Central Universities(lzujbky-2016-k10) ; Fundamental Research Funds for the Central Universities(lzujbky-2016-k10) ; open fund of State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics(T151402) ; open fund of State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics(T151402) |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/11352]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Lanzhou Univ, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Caihong,Fan, Jun,Sun, Xiuxia,et al. WS2 and MoS2 biosensing platforms using peptides as probe biomolecules[J]. SCIENTIFIC REPORTS,2017,7. |
| APA | Fu, Caihong.,Fan, Jun.,Sun, Xiuxia.,Xiao, Jianxi.,Wang, Jie.,...&Yao, Linyan.(2017).WS2 and MoS2 biosensing platforms using peptides as probe biomolecules.SCIENTIFIC REPORTS,7. |
| MLA | Fu, Caihong,et al."WS2 and MoS2 biosensing platforms using peptides as probe biomolecules".SCIENTIFIC REPORTS 7(2017). |
入库方式： OAI收割
来源：武汉物理与数学研究所
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