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High-resolution functional MRI identified distinct global intrinsic functional networks of nociceptive posterior insula and S2 regions in squirrel monkey brain

文献类型：期刊论文

作者Yang, Pai-Feng2,3; Chen, Li Min1,2,3; Wu, Ruiqi2,3,4; Wang, Feng2,3
刊名NEUROIMAGE
出版日期2017-07-15
卷号155页码:147-158
关键词Resting-state Functional Connectivity Whole Brain Pain Posterior Insula The Secondary Somatosensory Cortex Monkey
DOI10.1016/j.neuroimage.2017.04.067
文献子类Article
英文摘要Numerous functional imaging and electrophysiological studies in humans and animals indicate that the two contiguous areas of secondary somatosensory cortex (S2) and posterior insula (pIns) are core regions in nociceptive processing and pain perception. In this study, we tested the hypothesis that the S2-pIns connection serves as a hub for connecting distinct sensory and affective nociceptive processing networks in the squirrel monkey brain. At 9.4 T, we first mapped the brain regions that respond to nociceptive heat stimuli with high-resolution fMRI, and then used seed-based resting-state fMRI (rsfMRI) analysis to delineate and refine the global intrinsic functional connectivity circuits of the proximal S2 and pIns regions. In each subject, nociceptive (47.5 degrees C) heat-evoked fMRI activations were detected in many brain regions, including primary somatosensory (S1), S2, pIns, area 7b, anterior cingulate cortex (ACC), primary motor cortex, prefrontal cortex, supplementary motor area, thalamus, and caudate. Using the heat-evoked fMRI activation foci in S2 and pIns as the seeds, voxel-wise whole-brain resting-state functional connectivity (rsFC) analysis revealed strong functional connections between contralateral S2 and pIns, as well as their corresponding regions in the ipsilateral hemisphere. Spatial similarity and overlap analysis identified each region as part of two distinct intrinsic functional networks with 7% overlap: sensory S2-S1-area 7b and affective pIns-ACC-PCC networks. Moreover, a high degree of overlap was observed between the combined rsFC maps of nociceptive S2 and pIns regions and the nociceptive heat-evoked activation map. In summary, our study provides evidence for the existence of two distinct intrinsic functional networks for S2 and pIns nociceptive regions, and these two networks are joined via the S2-pIns connection. Brain regions that are involved in processing nociceptive inputs are also highly interconnected at rest. The presence of robust and distinct S1-S2-area 7b and pIns-ACC-PCC rsFC networks under anesthesia underscores their fundamental roles in processing nociceptive information.
WOS关键词ANTERIOR CINGULATE CORTEX ; SECONDARY SOMATOSENSORY CORTEX ; RESTING-STATE CONNECTIVITY ; LASER-EVOKED POTENTIALS ; CHRONIC PAIN ; PREFRONTAL CORTEX ; PARASYLVIAN CORTEX ; MOTOR CORTEX ; STIMULUS-INTENSITY ; NEUROPATHIC PAIN
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000405460900012
资助机构Dana Foundation ; Dana Foundation ; National Institutes of Health(R01 NS069909) ; National Institutes of Health(R01 NS069909) ; Dana Foundation ; Dana Foundation ; National Institutes of Health(R01 NS069909) ; National Institutes of Health(R01 NS069909)
源URL[http://ir.wipm.ac.cn/handle/112942/11440]  
专题武汉物理与数学研究所_磁共振应用研究部
作者单位1.Vanderbilt Univ, Dept Psychol, Nashville, TN 37232 USA
2.Vanderbilt Univ, Inst Imaging Sci, Nashville, TN 37232 USA
3.Vanderbilt Univ, Med Ctr, Dept Radiol & Radiol Sci, Nashville, TN 37232 USA
4.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Pai-Feng,Chen, Li Min,Wu, Ruiqi,et al. High-resolution functional MRI identified distinct global intrinsic functional networks of nociceptive posterior insula and S2 regions in squirrel monkey brain[J]. NEUROIMAGE,2017,155:147-158.
APA Yang, Pai-Feng,Chen, Li Min,Wu, Ruiqi,&Wang, Feng.(2017).High-resolution functional MRI identified distinct global intrinsic functional networks of nociceptive posterior insula and S2 regions in squirrel monkey brain.NEUROIMAGE,155,147-158.
MLA Yang, Pai-Feng,et al."High-resolution functional MRI identified distinct global intrinsic functional networks of nociceptive posterior insula and S2 regions in squirrel monkey brain".NEUROIMAGE 155(2017):147-158.

入库方式： OAI收割

来源：武汉物理与数学研究所

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