Salmonella typhimurium Infection Reduces Schistosoma japonicum Worm Burden in Mice
文献类型：期刊论文
| 作者 | Chen, Lu2; Zhu, Xiaoyang2; Wang, Yulan2,4; Tang, Huiru1,3; Wu, Junfang2 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017-05-02 |
| 卷号 | 7 |
| DOI | 10.1038/s41598-017-00992-1 |
| 文献子类 | Article |
| 英文摘要 | Coinfection of microorganisms is a common phenomenon in humans and animals. In order to further our understanding of the progress of coinfection and the possible interaction between different pathogens, we have built a coinfection mouse model with Schistosoma japonicum and Salmonella typhimurium, and used this model to investigate the systemic metabolic and immune responses using NMR-based metabonomics and immunological techniques. Our results show that Salmonella typhimurium (ATCC14028) infection reduces the number of adult schistosomal worms and eggs, relieves symptoms of schistosomiasis and also abates the mortality of mice infected by Schistosoma japonicum. In addition, Salmonella typhimurium infection counteracts the metabolic disturbances associated with schistosomiasis, which was reflected by the reverted levels of metabolites in coinfected mice, compared with the Schistosoma japonicum infected mice. Furthermore, immune analyses also indicate that shift of the immune response to different pathogens is a result of indirect interactions between Schistosoma japonicum and Salmonella typhimurium within the host. Salmonella typhimurium infection can ameliorate Schistosoma japonicum-caused schistosomiasis in BALB/c mice, which is most likely due to inverse immune polarization. Our work provides an insight into coinfection between Schistosoma japonicum and Salmonella typhimurium, and may further contribute to the development of new tools for controlling Schistosoma japonicum-associated diseases. |
| WOS关键词 | HUMAN-IMMUNODEFICIENCY-VIRUS ; IMMUNE-RESPONSE ; HEPATITIS-C ; POSITIVE PATIENTS ; COINFECTION ; HELMINTHS ; PARASITES ; CHILDREN ; TUBERCULOSIS ; METABONOMICS |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000400449700024 |
| 资助机构 | National Natural Science Foundation of China(21375144 ; National Natural Science Foundation of China(21375144 ; Ministry of Science and Technology of China(2012CB934004) ; Ministry of Science and Technology of China(2012CB934004) ; 21675169 ; 21675169 ; 91439102) ; 91439102) ; National Natural Science Foundation of China(21375144 ; National Natural Science Foundation of China(21375144 ; Ministry of Science and Technology of China(2012CB934004) ; Ministry of Science and Technology of China(2012CB934004) ; 21675169 ; 21675169 ; 91439102) ; 91439102) |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/11443]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Fudan Univ, Sch Life Sci, Collaborat Innovat Ctr Genet & Dev, Shanghai Int Ctr Mol Phen, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Peoples R China 3.Zhongshan Hosp, State Key Lab Genet Engn, Shanghai 200433, Peoples R China 4.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Lu,Zhu, Xiaoyang,Wang, Yulan,et al. Salmonella typhimurium Infection Reduces Schistosoma japonicum Worm Burden in Mice[J]. SCIENTIFIC REPORTS,2017,7. |
| APA | Chen, Lu,Zhu, Xiaoyang,Wang, Yulan,Tang, Huiru,&Wu, Junfang.(2017).Salmonella typhimurium Infection Reduces Schistosoma japonicum Worm Burden in Mice.SCIENTIFIC REPORTS,7. |
| MLA | Chen, Lu,et al."Salmonella typhimurium Infection Reduces Schistosoma japonicum Worm Burden in Mice".SCIENTIFIC REPORTS 7(2017). |
入库方式： OAI收割
来源：武汉物理与数学研究所
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