Long-term Ameliorative Effects of the Antidepressant Fluoxetine Exposure on Cognitive Deficits in 3 x TgAD Mice
文献类型：期刊论文
| 作者 | Sun, Dong-Sheng1,3; Jin, Li1,3; Gao, Li-Feng2; Wu, Hao2; Wang, Qun1,3; Ke, Dan1,3; Lei, Hao2; Wang, Jian-Zhi1,3,4; Liu, Gong-Ping1,3 |
| 刊名 | MOLECULAR NEUROBIOLOGY
 |
| 出版日期 | 2017-08-01 |
| 卷号 | 54期号:6页码:4160-4171 |
| 关键词 | Fluoxetine Alzheimer's Disease Cognitive Mri Bdnf |
| DOI | 10.1007/s12035-016-9952-9 |
| 文献子类 | Article |
| 英文摘要 | Fluoxetine, a selective serotonin reuptake inhibitor, is neuroprotective; therefore, it has been applied to treat some neurodegenerative disorders. For instance, chronic fluoxetine exposure has short-term effects on Alzheimer's disease (AD). However, the long-term ameliorative effects of fluoxetine exposure on AD have not been reported. In the present study, 6-month-old 3 x TgAD mice were treated with fluoxetine for 15 days, and then the influence of fluoxetine was detected at 20 days after the drug withdrawal. We found that chronic fluoxetine treatment ameliorated cognitive deficits of 3 x TgAD mice and increased the volume of the hippocampal CA1 and dentate gyrus (DG) with increased neuron number and dendritic spine density. Meanwhile, fluoxetine exposure also stimulated the long-term potentiation (LTP) in hippocampal DG. The synaptic-related protein expression increased via activation of the cyclic AMP response element binding (CREB) protein/brain-derived neurotrophic factor (BDNF) signaling pathway induced by fluoxetine exposure. Lastly, we found that fluoxetine treatment decreased beta-amyloid (A beta) levels. These results further certified that fluoxetine may be a potent effective drug for AD. |
| WOS关键词 | SPORADIC ALZHEIMERS-DISEASE ; TRANSGENIC MOUSE MODEL ; SYNAPTIC PLASTICITY ; CELL-PROLIFERATION ; MAJOR DEPRESSION ; ADMINISTRATION INCREASES ; NEUROTROPHIC FACTOR ; PREFRONTAL CORTEX ; DOUBLE-BLIND ; A-BETA |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000405710900020 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/11459]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Collaborat Innovat Ctr Brain Sci, Key Lab, Minist Educ China Neurol Disorders,Tongji Med Col, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan, Wuhan, Peoples R China 3.Huazhong Univ Sci & Technol, Dept Pathophysiol, Sch Basic Med, Wuhan 430030, Peoples R China 4.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, JS, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Dong-Sheng,Jin, Li,Gao, Li-Feng,et al. Long-term Ameliorative Effects of the Antidepressant Fluoxetine Exposure on Cognitive Deficits in 3 x TgAD Mice[J]. MOLECULAR NEUROBIOLOGY,2017,54(6):4160-4171. |
| APA | Sun, Dong-Sheng.,Jin, Li.,Gao, Li-Feng.,Wu, Hao.,Wang, Qun.,...&Liu, Gong-Ping.(2017).Long-term Ameliorative Effects of the Antidepressant Fluoxetine Exposure on Cognitive Deficits in 3 x TgAD Mice.MOLECULAR NEUROBIOLOGY,54(6),4160-4171. |
| MLA | Sun, Dong-Sheng,et al."Long-term Ameliorative Effects of the Antidepressant Fluoxetine Exposure on Cognitive Deficits in 3 x TgAD Mice".MOLECULAR NEUROBIOLOGY 54.6(2017):4160-4171. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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