Protein kinase M zeta and the maintenance of long-term memory
文献类型：期刊论文
| 作者 | Zhang, Yang1,2,3; Ma, Yuanye1,2; Zhang, Lei1,2,4; Wang, Jianhong1,2; Zong, Wei5 |
| 刊名 | NEUROCHEMISTRY INTERNATIONAL
 |
| 出版日期 | 2016-10-01 |
| 卷号 | 99页码:215-220 |
| 关键词 | Protein Kinase m Zeta (Pkm Zeta) Maintenance Of Long-term Memory Zeta Inhibitory Peptide (Zip) |
| DOI | 10.1016/j.neuint.2016.07.007 |
| 文献子类 | Review |
| 英文摘要 | Although various molecules have been found to mediate the processes of memory acquisition and consolidation, the molecular mechanism to maintain memory still remains elusive. In recent years, a molecular pathway focusing on protein kinase M zeta (PKM zeta) has become of interest to researchers because of its potential role in long-term memory maintenance. PKM zeta is an isoform of protein kinase C (PKC) and has a related structure that influences its function in maintaining memory. Considerable evidence has been gathered on PKM zeta activity, including loss of function studies using PKM zeta inhibitors, such as PKM zeta inhibitory peptide (ZIP), suggesting PKM zeta plays an important role in long-term memory maintenance. This review provides an overview of the role of PKM zeta in long-term memory and outlines the molecular structure of PKM zeta, the molecular mechanism of PKM zeta in long-term memory maintenance and future directions of PKM zeta research. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS关键词 | PKM-ZETA ; SYNAPTIC-TRANSMISSION ; DENDRITIC SPINES ; AMPA RECEPTORS ; DRUG-ADDICTION ; MESSENGER-RNA ; POTENTIATION ; LTP ; INSULA ; INHIBITION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000384778500022 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/11503]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China 2.Chinese Acad Sci, Yunnan Prov Kunming Inst Zool, Kunming 650223, Peoples R China 3.Shandong Assoc Sci & Technol, Jinan, Peoples R China 4.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst, Wuhan 430071, Peoples R China 5.Honghe Hlth Vocat Coll, Mengzi, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yang,Ma, Yuanye,Zhang, Lei,et al. Protein kinase M zeta and the maintenance of long-term memory[J]. NEUROCHEMISTRY INTERNATIONAL,2016,99:215-220. |
| APA | Zhang, Yang,Ma, Yuanye,Zhang, Lei,Wang, Jianhong,&Zong, Wei.(2016).Protein kinase M zeta and the maintenance of long-term memory.NEUROCHEMISTRY INTERNATIONAL,99,215-220. |
| MLA | Zhang, Yang,et al."Protein kinase M zeta and the maintenance of long-term memory".NEUROCHEMISTRY INTERNATIONAL 99(2016):215-220. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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