Correlated Disruption of Resting-State fMRI, LFP, and Spike Connectivity between Area 3b and S2 following Spinal Cord Injury in Monkeys
文献类型：期刊论文
| 作者 | Chen, Li Min1,3,4; Yang, Pai-Feng1,3; Wu, Ruiqi1,2,3 |
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2017-11-15 |
| 卷号 | 37期号:46页码:11192-11203 |
| 关键词 | Electrophysiology Functional Connectivity Fmri Nonhuman Primate Spinal Cord Injury |
| DOI | 10.1523/JNEUROSCI.2318-17.2017 |
| 文献子类 | Article |
| 英文摘要 | This study aims to understand how functional connectivity (FC) between areas 3b and S2 alters following input deprivation and the neuronal basis of disrupted FC of resting-state fMRI signals. We combined submillimeter fMRI with microelectrode recordings to localize the deafferented digit regions in areas 3b and S2 by mapping tactile stimulus-evoked fMRI activations before and after cervical dorsal column lesion in each male monkey. An average afferent disruption of 97% significantly reduced fMRI, local field potential (LFP), and spike responses to stimuli in both areas. Analysis of resting-state fMRI signal correlation, LFP coherence, and spike cross-correlation revealed significantly reduced functional connectivity between deafferented areas 3b and S2. The degrees of reductions in stimulus responsiveness and FC after deafferentation differed across fMRI, LFP, and spiking signals. The reduction of FC was much weaker than that of stimulus-evoked responses. Whereas the largest stimulus-evoked signal drop (similar to 80%) was observed in LFP signals, the greatest FC reduction was detected in the spiking activity (similar to 30%). fMRI signals showed mild reductions in stimulus responsiveness (similar to 25%) and FC (similar to 20%). The overall deafferentation-induced changes were quite similar in areas 3b and S2 across signals. Here we demonstrated that FC strength between areas 3b and S2 was much weakened by dorsal column lesion, and stimulus response reduction and FC disruption in fMRI covary with those of LFP and spiking signals in deafferented areas 3b and S2. These findings have important implications for fMRI studies aiming to probe FC alterations in pathological conditions involving deafferentation in humans. |
| WOS关键词 | LOCAL-FIELD POTENTIALS ; SOMATOSENSORY CORTICAL AREAS ; FUNCTIONAL CONNECTIVITY ; SQUIRREL-MONKEYS ; MACAQUE MONKEYS ; CHRONIC HEADACHE ; CORTEX ; REORGANIZATION ; BRAIN ; ORGANIZATION |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000416593800012 |
| 资助机构 | Dana Foundation ; Dana Foundation ; National Institutes of Health(R01 NS069909) ; National Institutes of Health(R01 NS069909) ; Dana Foundation ; Dana Foundation ; National Institutes of Health(R01 NS069909) ; National Institutes of Health(R01 NS069909) |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/11591]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Vanderbilt Univ, Inst Imaging Sci, Nashville, TN 37232 USA 2.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China 3.Vanderbilt Univ, Dept Radiol & Radiol Sci, Nashville, TN 37232 USA 4.Vanderbilt Univ, Dept Psychol, Nashville, TN 37232 USA |
| 推荐引用方式 GB/T 7714 | Chen, Li Min,Yang, Pai-Feng,Wu, Ruiqi. Correlated Disruption of Resting-State fMRI, LFP, and Spike Connectivity between Area 3b and S2 following Spinal Cord Injury in Monkeys[J]. JOURNAL OF NEUROSCIENCE,2017,37(46):11192-11203. |
| APA | Chen, Li Min,Yang, Pai-Feng,&Wu, Ruiqi.(2017).Correlated Disruption of Resting-State fMRI, LFP, and Spike Connectivity between Area 3b and S2 following Spinal Cord Injury in Monkeys.JOURNAL OF NEUROSCIENCE,37(46),11192-11203. |
| MLA | Chen, Li Min,et al."Correlated Disruption of Resting-State fMRI, LFP, and Spike Connectivity between Area 3b and S2 following Spinal Cord Injury in Monkeys".JOURNAL OF NEUROSCIENCE 37.46(2017):11192-11203. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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