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Corticosterone Signaling and a Lateral Habenula-Ventral Tegmental Area Circuit Modulate Compulsive Self-Injurious Behavior in a Rat Model

文献类型：期刊论文

作者Lau, Pak-Ming2; Xu, Lin1; Bi, Guo-Qiang2,3; Xu, Fuqiang5,6; He, Xiaobin5,6; Zhou, Hua4; Yang, Chaoyu2; Zhang, Keming2; Ding, Lufeng2; Li, Jinnan1
刊名JOURNAL OF NEUROSCIENCE
出版日期2018-06-06
卷号38期号:23页码:S251-S266
关键词Entopeduncular Nucleus Glucocorticoid Lateral Habenula Self-injurious Behavior Stress Ventral Tegmental Area
DOI10.1523/JNEUROSCI.2540-17.2018
文献子类Article
英文摘要Self-injurious behavior (SIB) is commonly observed in patients with neuropsychiatric disorders, as well as in nonclinical populations with stress-related mental-health problems. However, the exact circuitry mechanisms underlying SIB have remained poorly understood. Here, with bilateral injection of muscimol into the entopeduncular nucleus (EP), we established a rat model of SIB. Following the muscimol injection, the male rats exhibited in a dose-dependent manner stereotypic self-biting behavior that lasted for hours and often resulted in wounds of various severities. The SIB was associated with an elevated level of serum corticosterone and could be exacerbated by enhancing the corticosterone signaling and, conversely, alleviated by inhibiting the corticosterone signaling. Activity mapping using c-fos immunostaining, combined with connectivity mapping using herpes simplex virus-based anterograde tracing from the EP and pseudorabies virus-based retrograde tracing from the masseter muscle, revealed the potential involvement of many brain areas in SIB. In particular, the lateral habenula (LHb) and the ventral tegmental area (VTA), the two connected brain areas involved in stress response and reward processing, showed a significant increase in neuronal activation during SIB. Furthermore, suppressing the LHb activity or modulating the GABAergic transmission in the VTA could significantly reduce the occurrence of SIB. These results demonstrate the importance of stress hormone signaling and the LHb-VTA circuit in modulating SIB resulting from EP malfunction, and suggest potential targets for therapeutic intervention of SIB and related disorders.
WOS关键词DEEP BRAIN-STIMULATION ; LESCH-NYHAN DISEASE ; BASAL GANGLIA ; ENTOPEDUNCULAR NUCLEUS ; GLUTAMATERGIC NEURONS ; GLOBUS-PALLIDUS ; DOPAMINE ; STRESS ; RECEPTOR ; OUTPUT
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:000435412100002
资助机构Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02050002) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02050002) ; National Science Foundation of China(31130067 ; National Science Foundation of China(31130067 ; National Basic Research Program of China(2013CB835100) ; National Basic Research Program of China(2013CB835100) ; People's Government of Yunnan Province(2015HA0036) ; People's Government of Yunnan Province(2015HA0036) ; 31460262) ; 31460262) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02050002) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02050002) ; National Science Foundation of China(31130067 ; National Science Foundation of China(31130067 ; National Basic Research Program of China(2013CB835100) ; National Basic Research Program of China(2013CB835100) ; People's Government of Yunnan Province(2015HA0036) ; People's Government of Yunnan Province(2015HA0036) ; 31460262) ; 31460262)
源URL[http://ir.wipm.ac.cn/handle/112942/11973]  
专题武汉物理与数学研究所_数学物理与应用研究部
作者单位1.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Key Lab Anim Models & Human Dis Mech, Lab Learning & Memory,Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
2.Univ Sci & Technol China, Chinese Acad Sci, Sch Life Sci, Key Lab Brain Funct & Dis, Hefei 230027, Anhui, Peoples R China
3.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Sch Life Sci, Hefei 230027, Anhui, Peoples R China
4.Kunming Univ Sci & Technol, Fac Med, Kunming 650500, Yunnan, Peoples R China
5.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China
6.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China
推荐引用方式
GB/T 7714		 Lau, Pak-Ming,Xu, Lin,Bi, Guo-Qiang,et al. Corticosterone Signaling and a Lateral Habenula-Ventral Tegmental Area Circuit Modulate Compulsive Self-Injurious Behavior in a Rat Model[J]. JOURNAL OF NEUROSCIENCE,2018,38(23):S251-S266.
APA Lau, Pak-Ming.,Xu, Lin.,Bi, Guo-Qiang.,Xu, Fuqiang.,He, Xiaobin.,...&Guo, Yujie.(2018).Corticosterone Signaling and a Lateral Habenula-Ventral Tegmental Area Circuit Modulate Compulsive Self-Injurious Behavior in a Rat Model.JOURNAL OF NEUROSCIENCE,38(23),S251-S266.
MLA Lau, Pak-Ming,et al."Corticosterone Signaling and a Lateral Habenula-Ventral Tegmental Area Circuit Modulate Compulsive Self-Injurious Behavior in a Rat Model".JOURNAL OF NEUROSCIENCE 38.23(2018):S251-S266.

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来源：武汉物理与数学研究所

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