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Doxorubicin and paclitaxel carried by methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) is superior than traditional drug-delivery methods

文献类型：期刊论文

作者Song, Yipeng2; Wang, Jin2; Zhao, Ruifang3; Hu, Yili2; Zhu, Xiaoyang2; Wang, Yulan2,4; Tang, Huiru1,2; Nie, Guangjun3
刊名NANOMEDICINE
出版日期2018-04-01
卷号13期号:8页码:913-928
关键词Anticancer Drugs Biomedical Applications Metabonomics Nuclear Magnetic Resonance Nmr Polymer Nanoparticles
DOI10.2217/nnm-2017-0363
文献子类Article
英文摘要Aim: To evaluate the advantages of nanomaterial methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) (mPEG-PLGA) encapsulated doxorubicin (D/DOX) and paclitaxel (T/TAX; mPEG-PLGA-DT) over free form of DOX and TAX (DOX/TAX).Materia Is & methods: Metabonomics was conducted to characterize the systemic metabolic response of allograft breast cancer model mice to mPEG-PLGA-DT and DOX/TAX treatments. Results: Breast tumor growth induced metabolic reprogram in serum and multiple organs. DOX/TAX treatment could ameliorate the elevated energy and nucleotides demands in some organs while mPEG-PLGA-DT treatment showed outstanding therapeutic outcomes in restoring the metabolic phenotypes of serum and kidney from tumor-bearing mice to the healthy state. Conclusion: This investigation proved the biological advantages of mPEG-PLGA-DT over DOX/TAX in molecular level through the comparison between their metabolic responses in vivo.
WOS关键词HYPOXIA-INDUCIBLE FACTOR-1-ALPHA ; ENHANCED ANTITUMOR EFFICACY ; PLGA-PEG NANOPARTICLES ; BREAST-CANCER ; ENDOMETRIAL CARCINOMA ; GLUTATHIONE DEPLETION ; ANTICANCER DRUG ; CERVICAL-CANCER ; OVARIAN-CANCER ; LUNG-CANCER
WOS研究方向Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
语种英语
WOS记录号WOS:000432932200008
资助机构National Natural Science Foundation of China(21675169 ; National Natural Science Foundation of China(21675169 ; Ministry of Science and Technology 973(2017YFC0906800 ; Ministry of Science and Technology 973(2017YFC0906800 ; 21375144 ; 21375144 ; 2012CB934004) ; 2012CB934004) ; 91439102 ; 91439102 ; 81590953) ; 81590953) ; National Natural Science Foundation of China(21675169 ; National Natural Science Foundation of China(21675169 ; Ministry of Science and Technology 973(2017YFC0906800 ; Ministry of Science and Technology 973(2017YFC0906800 ; 21375144 ; 21375144 ; 2012CB934004) ; 2012CB934004) ; 91439102 ; 91439102 ; 81590953) ; 81590953)
源URL[http://ir.wipm.ac.cn/handle/112942/11979]  
专题武汉物理与数学研究所_磁共振应用研究部
作者单位1.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, State Key Lab Genet Engn, Metabol & Syst Biol Lab,Sch Life Sci, Shanghai 200433, Peoples R China
2.Univ Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, CAS Key Lab Magnet Resonance Biol Syst,State Key, Wuhan 430071, Hubei, Peoples R China
3.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosaftey, Beijing 100190, Peoples R China
4.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Song, Yipeng,Wang, Jin,Zhao, Ruifang,et al. Doxorubicin and paclitaxel carried by methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) is superior than traditional drug-delivery methods[J]. NANOMEDICINE,2018,13(8):913-928.
APA Song, Yipeng.,Wang, Jin.,Zhao, Ruifang.,Hu, Yili.,Zhu, Xiaoyang.,...&Nie, Guangjun.(2018).Doxorubicin and paclitaxel carried by methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) is superior than traditional drug-delivery methods.NANOMEDICINE,13(8),913-928.
MLA Song, Yipeng,et al."Doxorubicin and paclitaxel carried by methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) is superior than traditional drug-delivery methods".NANOMEDICINE 13.8(2018):913-928.

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来源：武汉物理与数学研究所

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