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Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice

文献类型：期刊论文

作者Patterson, Andrew D.2; Tian, Yuan2,3; Nichols, Robert G.2; Roy, Pratiti2; Gui, Wei2; Smith, Philip B.1; Zhang, Jingtao2; Lin, Yangding2; Weaver, Veronika2; Cai, Jingwei2
刊名JOURNAL OF FUNCTIONAL FOODS
出版日期2018-06-01
卷号45页码:223-232
关键词Mushroom Succinate Propionate Microbiota Intestinal Gluconeogenesis
DOI10.1016/j.jff.2018.04.008
文献子类Article
英文摘要The mechanisms by which white button (WB) mushrooms (Agaricus bisporus) may influence health are unclear. WB feeding (1%) resulted in changes in the composition of microbiota in conventional (CV) mice to expand a population of Prevotella that produce propionate and succinate. Microbial propionate and succinate production induced expression of genes important for intestinal gluconeogenesis (IGN) via the gut-brain neural circuit. Reduced hepatic glucose production was a metabolic benefit of IGN that was found in WB fed CV mice. In the absence of microbiota or in mice with disruptions in the ability to sense microbiota there was no WB mediated effect. WB-fed lean mice had a small but significant improvement in glucose sensitivity. WB feeding resulted in shifts in the microbiota that induced IGN and improved glucose homeostasis.
WOS关键词BRAIN NEURAL CIRCUITS ; GUT MICROBIOTA ; GLUCOSE-HOMEOSTASIS ; HOST METABOLISM ; VITAMIN-D ; OBESITY ; HEALTH ; PROPIONATE ; ERGOTHIONEINE ; SPECTROSCOPY
WOS研究方向Food Science & Technology
语种英语
WOS记录号WOS:000434494300026
资助机构Mushroom Council ; Mushroom Council ; American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56AI114972 ; National Institutes of Health(R56AI114972 ; R01AT005378) ; R01AT005378) ; Mushroom Council ; Mushroom Council ; American Association of Immunologists fellowship ; American Association of Immunologists fellowship ; National Institutes of Health(R56AI114972 ; National Institutes of Health(R56AI114972 ; R01AT005378) ; R01AT005378)
源URL[http://ir.wipm.ac.cn/handle/112942/11982]  
专题武汉物理与数学研究所_磁共振基础研究部
作者单位1.Penn State Univ, Huck Inst Life Sci, University Pk, PA 16802 USA
2.Penn State Univ, Dept Vet & Biomed Sci, University Pk, PA 16802 USA
3.Univ Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan,CAS Key Lab Magne, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Patterson, Andrew D.,Tian, Yuan,Nichols, Robert G.,et al. Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice[J]. JOURNAL OF FUNCTIONAL FOODS,2018,45:223-232.
APA Patterson, Andrew D..,Tian, Yuan.,Nichols, Robert G..,Roy, Pratiti.,Gui, Wei.,...&Cantorna, Margherita T..(2018).Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice.JOURNAL OF FUNCTIONAL FOODS,45,223-232.
MLA Patterson, Andrew D.,et al."Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice".JOURNAL OF FUNCTIONAL FOODS 45(2018):223-232.

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来源：武汉物理与数学研究所

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