Facile Synthesis of Novel Perfluorocarbon-Modulated 4-Anilinoquinazoline Analogues
文献类型：期刊论文
| 作者 | Shi, Huiping3; Lai, Bonan3; Chen, Shizhen1; Zhou, Xin1; Nie, Jing3; Ma, Jun-An2,3 |
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2017-11-01 |
| 卷号 | 35期号:11页码:1693-1700 |
| 关键词 | 4-anilinoquinazolines Perfluorocarbon (Pfc) Nucleophilic Substitution Reaction Synthesis Epidermal Growth Factor Receptor (Egfr) |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.201700240 |
| 文献子类 | Article |
| 英文摘要 | 4-Anilinoquinazoline analogues stand out among many kinds of small molecules that inhibit the tyrosine kinase activities of epidermal growth factor receptor (EGFR), thus serving as significant molecular targets for anticancer drug design. Herein, a series of novel perfluorocarbon (PFC) modulated 4-anilinoquinazolines were designed and prepared straightforwardly by nucleophilic substitution reaction of various anilinoquinazolines and PFC-derived methanesulfonate. In the presence of base, the reaction proceeded smoothly to afford a wide range of 4-anilinoquinazolines with different substituents on aniline moiety in good to high yields. Furthermore, the PFC-modified analogues of gefitinib and erlotinib were also obtained in 93% and 90% respectively, which may have potential for developing new inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase and fluorinated contrast agents (CA) for F-19 MRI. |
| WOS关键词 | KINASE INHIBITORS ; LUNG-CANCER ; TARGETED THERAPIES ; DESIGN |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000417173600007 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Natural Science Foundation of China(21532008 ; National Natural Science Foundation of China(21532008 ; Tianjin Municipal Science & Technology Commission(14JCQNJC06200) ; Tianjin Municipal Science & Technology Commission(14JCQNJC06200) ; 21472137) ; 21472137) ; National Natural Science Foundation of China(21532008 ; National Natural Science Foundation of China(21532008 ; Tianjin Municipal Science & Technology Commission(14JCQNJC06200) ; Tianjin Municipal Science & Technology Commission(14JCQNJC06200) ; 21472137) ; 21472137) ; National Natural Science Foundation of China(21532008 ; National Natural Science Foundation of China(21532008 ; Tianjin Municipal Science & Technology Commission(14JCQNJC06200) ; Tianjin Municipal Science & Technology Commission(14JCQNJC06200) ; 21472137) ; 21472137) ; National Natural Science Foundation of China(21532008 ; National Natural Science Foundation of China(21532008 ; Tianjin Municipal Science & Technology Commission(14JCQNJC06200) ; Tianjin Municipal Science & Technology Commission(14JCQNJC06200) ; 21472137) ; 21472137) |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/12748]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Nie, Jing; Ma, Jun-An |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Hubei, Peoples R China 2.Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China 3.Tianjin Univ, Tianjin Key Lab Mol Optoelect Sci, Dept Chem, Tianjin 300072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Huiping,Lai, Bonan,Chen, Shizhen,et al. Facile Synthesis of Novel Perfluorocarbon-Modulated 4-Anilinoquinazoline Analogues[J]. CHINESE JOURNAL OF CHEMISTRY,2017,35(11):1693-1700. |
| APA | Shi, Huiping,Lai, Bonan,Chen, Shizhen,Zhou, Xin,Nie, Jing,&Ma, Jun-An.(2017).Facile Synthesis of Novel Perfluorocarbon-Modulated 4-Anilinoquinazoline Analogues.CHINESE JOURNAL OF CHEMISTRY,35(11),1693-1700. |
| MLA | Shi, Huiping,et al."Facile Synthesis of Novel Perfluorocarbon-Modulated 4-Anilinoquinazoline Analogues".CHINESE JOURNAL OF CHEMISTRY 35.11(2017):1693-1700. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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