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The interhemispheric CA1 circuit governs rapid generalisation but not fear memory

文献类型：期刊论文

作者Zhou, Heng2,3,6; Xiong, Gui-Jing2,3; Xu, Fu-Qiang8,9; Jing, Liang2,3,4,5; Song, Ning-Ning1,7,13; Pu, De-Lin2,3; Tang, Xun6; He, Xiao-Bing8; Huang, Jing-Fei10; Li, Ling-Jiang11
刊名NATURE COMMUNICATIONS
出版日期2017-12-19
卷号8
ISSN号2041-1723
DOI10.1038/s41467-017-02315-4
文献子类Article
英文摘要Encoding specificity theory predicts most effective recall by the original conditions at encoding, while generalization endows recall flexibly under circumstances which deviate from the originals. The CA1 regions have been implicated in memory and generalization but whether and which locally separated mechanisms are involved is not clear. We report here that fear memory is quickly formed, but generalization develops gradually over 24 h. Generalization but not fear memory is impaired by inhibiting ipsilateral (ips) or contralateral (con) CA1, and by optogenetic silencing of the ipsCA1 projections onto conCA1. By contrast, in vivo fEPSP recordings reveal that ipsCA1-conCA1 synaptic efficacy is increased with delay over 24 h when generalization is formed but it is unchanged if generalization is disrupted. Direct excitation of ipsCA1-conCA1 synapses using chemogenetic hM3Dq facilitates generalization formation. Thus, rapid generalization is an active process dependent on bilateral CA1 regions, and encoded by gradual synaptic learning in ipsCA1-conCA1 circuit.
WOS关键词LONG-TERM POTENTIATION ; COMPLEMENTARY LEARNING-SYSTEMS ; DORSAL HIPPOCAMPAL COMMISSURE ; ANTERIOR CINGULATE CORTEX ; SYNAPTIC PLASTICITY ; ADULT NEUROGENESIS ; CENTRAL SEROTONIN ; STRESS-DISORDER ; RAT HIPPOCAMPUS ; MECHANISMS
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000418336400013
资助机构Ministry of Science and Technology of China(2013CB835100 ; Ministry of Science and Technology of China(2013CB835100 ; Chinese Academy of Sciences(XDB02020002) ; Chinese Academy of Sciences(XDB02020002) ; External Cooperation Program BIC of Chinese Academy of Sciences(GJHZ1549) ; External Cooperation Program BIC of Chinese Academy of Sciences(GJHZ1549) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2013250) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2013250) ; National Science Foundation of China(31100775 ; National Science Foundation of China(31100775 ; Science and Technology Program of Yunnan Province(2013GA003) ; Science and Technology Program of Yunnan Province(2013GA003) ; 2015CB553502) ; 2015CB553502) ; 31371141 ; 31371141 ; 8157332 ; 8157332 ; U1502221) ; U1502221) ; Ministry of Science and Technology of China(2013CB835100 ; Ministry of Science and Technology of China(2013CB835100 ; Chinese Academy of Sciences(XDB02020002) ; Chinese Academy of Sciences(XDB02020002) ; External Cooperation Program BIC of Chinese Academy of Sciences(GJHZ1549) ; External Cooperation Program BIC of Chinese Academy of Sciences(GJHZ1549) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2013250) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2013250) ; National Science Foundation of China(31100775 ; National Science Foundation of China(31100775 ; Science and Technology Program of Yunnan Province(2013GA003) ; Science and Technology Program of Yunnan Province(2013GA003) ; 2015CB553502) ; 2015CB553502) ; 31371141 ; 31371141 ; 8157332 ; 8157332 ; U1502221) ; U1502221) ; Ministry of Science and Technology of China(2013CB835100 ; Ministry of Science and Technology of China(2013CB835100 ; Chinese Academy of Sciences(XDB02020002) ; Chinese Academy of Sciences(XDB02020002) ; External Cooperation Program BIC of Chinese Academy of Sciences(GJHZ1549) ; External Cooperation Program BIC of Chinese Academy of Sciences(GJHZ1549) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2013250) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2013250) ; National Science Foundation of China(31100775 ; National Science Foundation of China(31100775 ; Science and Technology Program of Yunnan Province(2013GA003) ; Science and Technology Program of Yunnan Province(2013GA003) ; 2015CB553502) ; 2015CB553502) ; 31371141 ; 31371141 ; 8157332 ; 8157332 ; U1502221) ; U1502221) ; Ministry of Science and Technology of China(2013CB835100 ; Ministry of Science and Technology of China(2013CB835100 ; Chinese Academy of Sciences(XDB02020002) ; Chinese Academy of Sciences(XDB02020002) ; External Cooperation Program BIC of Chinese Academy of Sciences(GJHZ1549) ; External Cooperation Program BIC of Chinese Academy of Sciences(GJHZ1549) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2013250) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2013250) ; National Science Foundation of China(31100775 ; National Science Foundation of China(31100775 ; Science and Technology Program of Yunnan Province(2013GA003) ; Science and Technology Program of Yunnan Province(2013GA003) ; 2015CB553502) ; 2015CB553502) ; 31371141 ; 31371141 ; 8157332 ; 8157332 ; U1502221) ; U1502221)
源URL[http://ir.wipm.ac.cn/handle/112942/12750]  
专题中国科学院武汉物理与数学研究所
通讯作者Zhou, Qi-Xin; Ding, Yu-Qiang; Xu, Lin
作者单位1.Tongji Univ, Sch Med, Key Lab Arrhythmias, Minist Educ,East Hosp, Shanghai 200092, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Lab Learning & Memory, Kunming 650223, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
4.Univ Haifa, Dept Neurobiol & Ethol, IL-3498838 Haifa, Israel
5.Univ Haifa, Dept Psychol, IL-3498838 Haifa, Israel
6.Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China
7.Tongji Univ, Sch Med, Dept Anat & Neurobiol, Collaborat Innovat Ctr Brain Sci, Shanghai 200092, Peoples R China
8.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China
9.CAS Ctr Excellence Brain Sci & Intelligent Techno, Shanghai 200031, Peoples R China
10.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Heng,Xiong, Gui-Jing,Xu, Fu-Qiang,et al. The interhemispheric CA1 circuit governs rapid generalisation but not fear memory[J]. NATURE COMMUNICATIONS,2017,8.
APA Zhou, Heng.,Xiong, Gui-Jing.,Xu, Fu-Qiang.,Jing, Liang.,Song, Ning-Ning.,...&Xu, Lin.(2017).The interhemispheric CA1 circuit governs rapid generalisation but not fear memory.NATURE COMMUNICATIONS,8.
MLA Zhou, Heng,et al."The interhemispheric CA1 circuit governs rapid generalisation but not fear memory".NATURE COMMUNICATIONS 8(2017).

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来源：武汉物理与数学研究所

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