Metabolic profile of visual cortex in diabetic rats measured with in vivo proton MRS
文献类型：期刊论文
| 作者 | Li, Shuang1; Wang, Xinghua3; Yang, Junjie3; Lei, Hao2; Wang, Xuxia2; Xiang, Yi1 |
| 刊名 | NMR IN BIOMEDICINE
 |
| 出版日期 | 2017-11-01 |
| 卷号 | 30期号:11 |
| 关键词 | Diabetes Metabolism Mrs Retinal Ganglion Cells Visual Cortex |
| ISSN号 | 0952-3480 |
| DOI | 10.1002/nbm.3783 |
| 文献子类 | Article |
| 英文摘要 | The purpose of the present study was to characterize the metabolic profile of the visual cortex in streptozotocin-induced Type 1 diabetic rats by means of in vivo proton MRS. Several metabolite concentration ratios in the visual cortex were calculated. In addition, postmortem histologic analyses for retinal ganglion cell (RGC) loss, optic nerve injury and visual cortex alterations were monitored. The results showed that diabetes induced several changes in visual cortex metabolites, such as reducedN-acetylaspartate, glutamate, gamma-aminobutyric acid, taurine and choline-containing compound levels. Nevertheless, myo-inositol levels increased significantly as compared with controls. Remarkable RGC loss and optic nerve degeneration were observed by morphological analysis. Moreover, the results showed significant neuronal loss and glial activation in the visual cortex. These findings indicated that, besides vascular abnormalities, neuronal loss and degeneration in the visual pathway were induced due to disrupted glucose homeostasis in diabetes. Metabolic or functional abnormalities were induced in cerebral neurons of the visual cortex by diabetes. |
| WOS关键词 | MAGNETIC-RESONANCE-SPECTROSCOPY ; RETINAL GANGLION-CELLS ; CEREBRAL METABOLISM ; BRAIN-METABOLITES ; WHITE-MATTER ; EARLY-ONSET ; RETINOPATHY ; MELLITUS ; APOPTOSIS ; EXERCISE |
| WOS研究方向 | Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy |
| 语种 | 英语 |
| WOS记录号 | WOS:000417914100018 |
| 出版者 | WILEY |
| 资助机构 | National Natural Science Foundation of China(81300761) ; National Natural Science Foundation of China(81300761) ; National Natural Science Foundation of China(81300761) ; National Natural Science Foundation of China(81300761) ; National Natural Science Foundation of China(81300761) ; National Natural Science Foundation of China(81300761) ; National Natural Science Foundation of China(81300761) ; National Natural Science Foundation of China(81300761) |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/12756]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Wang, Xuxia; Xiang, Yi |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Ophthalmol, Wuhan 430014, Hubei, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan, Wuhan 430071, Hubei, Peoples R China 3.Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Ophthalmol, Wuhan 430022, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Shuang,Wang, Xinghua,Yang, Junjie,et al. Metabolic profile of visual cortex in diabetic rats measured with in vivo proton MRS[J]. NMR IN BIOMEDICINE,2017,30(11). |
| APA | Li, Shuang,Wang, Xinghua,Yang, Junjie,Lei, Hao,Wang, Xuxia,&Xiang, Yi.(2017).Metabolic profile of visual cortex in diabetic rats measured with in vivo proton MRS.NMR IN BIOMEDICINE,30(11). |
| MLA | Li, Shuang,et al."Metabolic profile of visual cortex in diabetic rats measured with in vivo proton MRS".NMR IN BIOMEDICINE 30.11(2017). |
入库方式： OAI收割
来源：武汉物理与数学研究所
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