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Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward

文献类型：期刊论文

作者Xu, Fuqiang3,4; Wang, Liping; Cao, Pei4; Li, Haohong3; Lv, Guanghui3; Luo, Rui2; Xu, Xiaoran2; Zhang, Xueyi2; Zhou, Zheng1,5; Li, Juan4
刊名ELIFE
出版日期2017-12-16
卷号6
ISSN号2050-084X
DOI10.7554/eLife.25423
文献子类Article
英文摘要Odor-preferences are usually influenced by life experiences. However, the neural circuit mechanisms remain unclear. The medial olfactory tubercle (mOT) is involved in both reward and olfaction, whereas the ventral tegmental area (VTA) dopaminergic (DAergic) neurons are considered to be engaged in reward and motivation. Here, we found that the VTA (DAergic)-mOT pathway could be activated by different types of naturalistic rewards as well as odors in DAT-cre mice. Optogenetic activation of the VTA-mOT DAergic fibers was able to elicit preferences for space, location and neutral odor, while pharmacological blockade of the dopamine receptors in the mOT fully prevented the odor-preference formation. Furthermore, inactivation of the mOT-projecting VTA DAergic neurons eliminated the previously formed odor-preference and strongly affected the Go-no go learning efficiency. In summary, our results revealed that the VTA (DAergic)-mOT pathway mediates a variety of naturalistic reward processes and different types of preferences including odor-preference in mice.
WOS关键词VENTRAL TEGMENTAL AREA ; NUCLEUS-ACCUMBENS ; NEURAL REPRESENTATION ; PROJECTION SYSTEMS ; C-FOS ; RAT ; NEURONS ; RECEPTORS ; MIDBRAIN ; DYNAMICS
WOS研究方向Life Sciences & Biomedicine - Other Topics
语种英语
WOS记录号WOS:000423033300001
出版者ELIFE SCIENCES PUBLICATIONS LTD
资助机构National Natural Science Foundation of China(31400945 ; National Natural Science Foundation of China(31400945 ; Ministry of Science and Technology of the People's Republic of China(2015CB755600) ; Ministry of Science and Technology of the People's Republic of China(2015CB755600) ; Chinese Academy of Sciences(XDB02050005) ; Chinese Academy of Sciences(XDB02050005) ; 31400946 ; 31400946 ; 31400977 ; 31400977 ; 81661148053 ; 81661148053 ; 91632303 ; 91632303 ; 31771156) ; 31771156) ; National Natural Science Foundation of China(31400945 ; National Natural Science Foundation of China(31400945 ; Ministry of Science and Technology of the People's Republic of China(2015CB755600) ; Ministry of Science and Technology of the People's Republic of China(2015CB755600) ; Chinese Academy of Sciences(XDB02050005) ; Chinese Academy of Sciences(XDB02050005) ; 31400946 ; 31400946 ; 31400977 ; 31400977 ; 81661148053 ; 81661148053 ; 91632303 ; 91632303 ; 31771156) ; 31771156) ; National Natural Science Foundation of China(31400945 ; National Natural Science Foundation of China(31400945 ; Ministry of Science and Technology of the People's Republic of China(2015CB755600) ; Ministry of Science and Technology of the People's Republic of China(2015CB755600) ; Chinese Academy of Sciences(XDB02050005) ; Chinese Academy of Sciences(XDB02050005) ; 31400946 ; 31400946 ; 31400977 ; 31400977 ; 81661148053 ; 81661148053 ; 91632303 ; 91632303 ; 31771156) ; 31771156) ; National Natural Science Foundation of China(31400945 ; National Natural Science Foundation of China(31400945 ; Ministry of Science and Technology of the People's Republic of China(2015CB755600) ; Ministry of Science and Technology of the People's Republic of China(2015CB755600) ; Chinese Academy of Sciences(XDB02050005) ; Chinese Academy of Sciences(XDB02050005) ; 31400946 ; 31400946 ; 31400977 ; 31400977 ; 81661148053 ; 81661148053 ; 91632303 ; 91632303 ; 31771156) ; 31771156)
源URL[http://ir.wipm.ac.cn/handle/112942/12780]  
专题中国科学院武汉物理与数学研究所
通讯作者Xu, Fuqiang
作者单位1.Chinese Acad Sci, Shenzhen Inst Adv Technol, CAS Ctr Excellence Brain Sci, Collaborat Innovat Ctr Brain Sci, Shenzhen, Peoples R China
2.Wuhan Univ, Coll Life Sci, Wuhan, Hubei, Peoples R China
3.Wuhan Natl Lab Optoelect, Wuhan, Hubei, Peoples R China
4.Chinese Acad Sci, Wuhan Inst Phys & Math, Ctr Brain Sci, Key Lab Magnet Resonance Biol Syst, Wuhan, Hubei, Peoples R China
5.Chinese Acad Sci, Shenzhen Inst Adv Technol, CAS Ctr Excellence Brain Sci, Shenzhen Key Lab Neuropsychiat Modulat, Shenzhen, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Fuqiang,Wang, Liping,Cao, Pei,et al. Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward[J]. ELIFE,2017,6.
APA Xu, Fuqiang.,Wang, Liping.,Cao, Pei.,Li, Haohong.,Lv, Guanghui.,...&Zhang, Zhijian.(2017).Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward.ELIFE,6.
MLA Xu, Fuqiang,et al."Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward".ELIFE 6(2017).

入库方式： OAI收割

来源：武汉物理与数学研究所

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