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Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents

文献类型：期刊论文

作者Li, Jielan2; Gui, Xi'en3; Lin, Fuchun1; Lei, Hao1; Tu, Ning2; Wang, Panying2; Zhang, Jing2; Wen, Zhi2; Gao, Lei2; Wu, Guangyao2
刊名SCIENTIFIC REPORTS
出版日期2018-01-19
卷号8
ISSN号2045-2322
DOI10.1038/s41598-018-19290-5
文献子类Article
英文摘要Human immunodeficiency virus (HIV) infection significantly affect neurodevelopmental and behavioral outcomes. We investigated whether alterations of gray matter organization and structural covariance networks with vertical HIV infection adolescents exist, by using the GAT toolbox. MRI data were analysed from 25 HIV vertically infected adolescents and 33 HIV-exposed-uninfected control participants. The gray matter volume (GMV) was calculated, and structural brain networks were reconstructed from gray matter co-variance. Gray matter losses were pronounced in anterior cingulate cortex (ACC), right pallidum, right occipital lobe, inferior parietal lobe, and bilateral cerebellum crus. The global brain network measures were not significantly different between the groups; however, the nodal alterations were most pronounced in frontal, temporal, basal ganglia, cerebellum, and temporal lobes. Brain hubs in the HIV-infected subjects increased in number and tended to shift to sensorimotor and temporal areas. In the HIV-infected subjects, decreased GMVs in ACC and bilateral cerebellum were related to lower Mini-Mental State Examination scores; the CD4 counts were positively related to the GMVs in ACC and sensorimotor areas. These findings suggest that focally reduced gray matter, disrupted nodal profiles of structural wirings, and a shift in hub distribution may represent neuroanatomical biomarkers of HIV infection on the developing brain.
WOS关键词HUMAN CORTICAL NETWORKS ; BRAIN NETWORKS ; ANTIRETROVIRAL THERAPY ; THEORETICAL ANALYSIS ; MULTIPLE-SCLEROSIS ; SPATIAL STATISTICS ; PEDIATRIC HIV ; CHILDREN ; ORGANIZATION ; CEREBELLAR
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000422891000012
出版者NATURE PUBLISHING GROUP
资助机构National Natural Science Foundation of China (NSFC)(81171315 ; National Natural Science Foundation of China (NSFC)(81171315 ; 81227902) ; 81227902) ; National Natural Science Foundation of China (NSFC)(81171315 ; National Natural Science Foundation of China (NSFC)(81171315 ; 81227902) ; 81227902) ; National Natural Science Foundation of China (NSFC)(81171315 ; National Natural Science Foundation of China (NSFC)(81171315 ; 81227902) ; 81227902) ; National Natural Science Foundation of China (NSFC)(81171315 ; National Natural Science Foundation of China (NSFC)(81171315 ; 81227902) ; 81227902)
源URL[http://ir.wipm.ac.cn/handle/112942/12782]  
专题中国科学院武汉物理与数学研究所
通讯作者Wu, Guangyao
作者单位1.Chinese Acad Sci, Natl Ctr Magnet Resonance Wuhan, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan, Hubei, Peoples R China
2.Wuhan Univ, Zhongnan Hosp, Dept Magnet Resonance Imaging, Wuhan, Hubei, Peoples R China
3.Wuhan Univ, Zhongnan Hosp, Dept Infect Dis, Wuhan, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Li, Jielan,Gui, Xi'en,Lin, Fuchun,et al. Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents[J]. SCIENTIFIC REPORTS,2018,8.
APA Li, Jielan.,Gui, Xi'en.,Lin, Fuchun.,Lei, Hao.,Tu, Ning.,...&Wu, Guangyao.(2018).Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents.SCIENTIFIC REPORTS,8.
MLA Li, Jielan,et al."Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents".SCIENTIFIC REPORTS 8(2018).

入库方式： OAI收割

来源：武汉物理与数学研究所

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