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Colon Ascendens Stent Peritonitis (CASP) Induces Excessive Inflammation and Systemic Metabolic Dysfunction in a Septic Rat Model

文献类型：期刊论文

作者Zhang, Limin2; Tian, Yuan2; Yang, Jianfen3; Li, Jieshou3; Tang, Huiru4; Wang, Yulan1,2
刊名JOURNAL OF PROTEOME RESEARCH
出版日期2018
卷号17期号:1页码:680-688
关键词Casp Sepsis Nmr-based Metabolomics Inflammation
ISSN号1535-3893
DOI10.1021/acs.jproteome.7b00730
文献子类Article
英文摘要The colon ascendens stent peritonitis (CASP) surgery induces a leakage of gut contents, causing polymicrobial sepsis related to post-operative multiple organ failure and death in surgical patient. To evaluate the effects of GASP on multiple organs, we analyzed the systemic metabolic consequences in liver, kidney, lung, and heart of rats after GASP by employing a combination of metabolomics, clinical chemistry, and biological assays. We found that CASP surgery after 18 h resulted in striking elevations of lipid, amino acids, acetate, choline, PC, and GPC in rat liver together with significant depletion of glucose and glycogen. Marked elevations of organic acids including lactate, acetate, and creatine and amino acids accompanied by decline of glucose, betaine, TMAO, choline metabolites (PC and GPC) nucleotides, and a range of organic osmolytes such as myo-inositol are observed in the kidney of 18 h post-operative rat. Furthermore, 18 h post-operative rats exhibited accumulations of lipid, amino acids, and depletions of taurine, myo-inositol, choline, PC, and GPC and some nucleotides including uridine, inosine, and adenosine in the lung. In addition, significant elevations of some amino acids, uracil, betaine, and choline metabolites, together with depletion of inosine-S'-monophosphate, were only observed in the heart of 18 h post-operative rats. These results provide new insights into pathological consequences of CASP surgery, which are important for timely prognosis of sepsis.
WOS关键词POLYMICROBIAL SEPSIS ; CECAL LIGATION ; INFECTION ; MICE ; PATHOPHYSIOLOGY ; PROLIFERATION ; PUNCTURE ; HOST
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000419749800061
出版者AMER CHEMICAL SOC
资助机构National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006) ; National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006) ; National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006) ; National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006)
源URL[http://ir.wipm.ac.cn/handle/112942/12820]  
专题中国科学院武汉物理与数学研究所
通讯作者Zhang, Limin; Wang, Yulan
作者单位1.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Dis, Hangzhou 310058, Zhejiang, Peoples R China
2.Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, State Key Lab Magnet Resonance & Atom & Mol Phys,C, Wuhan 430071, Hubei, Peoples R China
3.Gen Hosp Nanjing Mil Reg, Res Inst Gen Surg, Nanjing 210002, Jiangsu, Peoples R China
4.Fudan Univ, Zhongshan Hosp, Sch Life Sci,State Key Lab Genet Engn, Shanghai Int Ctr Mol Phen,Collaborat Innovat Ctr, Shanghai 200433, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Limin,Tian, Yuan,Yang, Jianfen,et al. Colon Ascendens Stent Peritonitis (CASP) Induces Excessive Inflammation and Systemic Metabolic Dysfunction in a Septic Rat Model[J]. JOURNAL OF PROTEOME RESEARCH,2018,17(1):680-688.
APA Zhang, Limin,Tian, Yuan,Yang, Jianfen,Li, Jieshou,Tang, Huiru,&Wang, Yulan.(2018).Colon Ascendens Stent Peritonitis (CASP) Induces Excessive Inflammation and Systemic Metabolic Dysfunction in a Septic Rat Model.JOURNAL OF PROTEOME RESEARCH,17(1),680-688.
MLA Zhang, Limin,et al."Colon Ascendens Stent Peritonitis (CASP) Induces Excessive Inflammation and Systemic Metabolic Dysfunction in a Septic Rat Model".JOURNAL OF PROTEOME RESEARCH 17.1(2018):680-688.

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来源：武汉物理与数学研究所

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