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Evaluation of metabolites extraction strategies for identifying different brain regions and their relationship with alcohol preference and gender difference using NMR metabolomics

文献类型：期刊论文

作者Wang, Jie2; Zeng, Hao-Long3; Du, Hongying4; Liu, Zeyuan2; Cheng, Ji2; Liu, Taotao5; Hu, Ting2; Kamal, Ghulam Mustafa7; Li, Xihai8; Liu, Huili2
刊名TALANTA
出版日期2018-03-01
卷号179页码:369-376
关键词Metabolomics Decision Tree Principal Component Analysis (Pca) Alcohol Preference Brain Regions
ISSN号0039-9140
DOI10.1016/j.talanta.2017.11.045
文献子类Article
英文摘要Metabolomics generate a profile of small molecules from cellular/tissue metabolism, which could directly reflect the mechanisms of complex networks of biochemical reactions. Traditional metabolomics methods, such as OPTS-DA, PIS-DA are mainly used for binary class discrimination. Multiple groups are always involved in the biological system, especially for brain research. Multiple brain regions are involved in the neuronal study of brain metabolic dysfunctions such as alcoholism, Alzheimer's disease, etc. In the current study, 10 different brain regions were utilized for comparative studies between alcohol preferring and non-preferring rats, male and female rats respectively. As many classes are involved (ten different regions and four types of animals), traditional metabolomics methods are no longer efficient for showing differentiation. Here, a novel strategy based on the decision tree algorithm was employed for successfully constructing different classification models to screen out the major characteristics of ten brain regions at the same time. Subsequently, this method was also utilized to select the major effective brain regions related to alcohol preference and gender difference. Compared with the traditional multivariate statistical methods, the decision tree could construct acceptable and understandable classification models for multi-class data analysis. Therefore, the current technology could also be applied to other general metabolomics studies involving multi class data.
WOS关键词MAGNETIC-RESONANCE-SPECTROSCOPY ; CHRONIC ETHANOL EXPOSURE ; RAT-BRAIN ; SEX-DIFFERENCES ; DECISION TREES ; SPECTRA ; DISCRIMINATION ; DISORDERS ; GLUTAMATE ; TOXICITY
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000424178000050
出版者ELSEVIER SCIENCE BV
资助机构Chinese Ministry of Science and Technology(2015AA020508) ; Chinese Ministry of Science and Technology(2015AA020508) ; National Natural Science Foundation (NSF) of Hubei Province(2015CFB296) ; National Natural Science Foundation (NSF) of Hubei Province(2015CFB296) ; National Natural Science Foundation of China(31501495 ; National Natural Science Foundation of China(31501495 ; 31600666) ; 31600666) ; Chinese Ministry of Science and Technology(2015AA020508) ; Chinese Ministry of Science and Technology(2015AA020508) ; National Natural Science Foundation (NSF) of Hubei Province(2015CFB296) ; National Natural Science Foundation (NSF) of Hubei Province(2015CFB296) ; National Natural Science Foundation of China(31501495 ; National Natural Science Foundation of China(31501495 ; 31600666) ; 31600666) ; Chinese Ministry of Science and Technology(2015AA020508) ; Chinese Ministry of Science and Technology(2015AA020508) ; National Natural Science Foundation (NSF) of Hubei Province(2015CFB296) ; National Natural Science Foundation (NSF) of Hubei Province(2015CFB296) ; National Natural Science Foundation of China(31501495 ; National Natural Science Foundation of China(31501495 ; 31600666) ; 31600666) ; Chinese Ministry of Science and Technology(2015AA020508) ; Chinese Ministry of Science and Technology(2015AA020508) ; National Natural Science Foundation (NSF) of Hubei Province(2015CFB296) ; National Natural Science Foundation (NSF) of Hubei Province(2015CFB296) ; National Natural Science Foundation of China(31501495 ; National Natural Science Foundation of China(31501495 ; 31600666) ; 31600666)
源URL[http://ir.wipm.ac.cn/handle/112942/12852]  
专题中国科学院武汉物理与数学研究所
通讯作者Wang, Jie; Xu, Fuqiang
作者单位1.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China
2.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, Wuhan, Hubei, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongii Hosp, Dept Lab Med, Wuhan, Hubei, Peoples R China
4.Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan, Hubei, Peoples R China
5.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing, Peoples R China
6.Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Wuhan, Hubei, Peoples R China
7.Univ Faisalabad, Govt Coll, Dept Chem, Faisalabad 38000, Pakistan
8.Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou, Fujian, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Jie,Zeng, Hao-Long,Du, Hongying,et al. Evaluation of metabolites extraction strategies for identifying different brain regions and their relationship with alcohol preference and gender difference using NMR metabolomics[J]. TALANTA,2018,179:369-376.
APA Wang, Jie.,Zeng, Hao-Long.,Du, Hongying.,Liu, Zeyuan.,Cheng, Ji.,...&Xu, Fuqiang.(2018).Evaluation of metabolites extraction strategies for identifying different brain regions and their relationship with alcohol preference and gender difference using NMR metabolomics.TALANTA,179,369-376.
MLA Wang, Jie,et al."Evaluation of metabolites extraction strategies for identifying different brain regions and their relationship with alcohol preference and gender difference using NMR metabolomics".TALANTA 179(2018):369-376.

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来源：武汉物理与数学研究所

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