Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats
文献类型：期刊论文
| 作者 | Zhang, Limin2; Dong, Manyuan2; Xu, Guangyong2,3; Tian, Yuan2; Tang, Huiru1; Wang, Yulan2,4 |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2018-02-21 |
| 卷号 | 66期号:7页码:1723-1731 |
| 关键词 | Ferulic Acid Quercetin Bioavailability Bioactivity Metabolomics |
| ISSN号 | 0021-8561 |
| 文献子类 | Article |
| 英文摘要 | Phenolic compounds ingestion has been shown to have potential preventive and therapeutic effects against various metabolic diseases such as obesity and cancer. To provide a better understanding of these potential benefit effects, we investigated the metabolic alterations in urine and feces of rat ingested ferulic acid (FA) and quercetin (Qu) using NMR-based metabolomics approach. Our results suggested that dietary FA and/or Qu significantly decreased short chain fatty acids and elevated oligosaccharides in the feces, implying that dietary FA and Qu may modulate gut microbial community with inhibition of bacterial fermentation of dietary fibers. We also found that dietary FA and/or Qu regulated several host metabolic pathways including TCA cycle and energy metabolism, bile acid, amino acid, and nucleic acid metabolism. These biological effects suggest that FA and Qu display outstanding bioavailability and bioactivity and could be used for treatment of some metabolic syndromes, such as inflammatory bowel diseases and obesity. |
| WOS关键词 | POTENTIALLY ANTICARCINOGENIC FLAVONOIDS ; HYDROCARBON RECEPTOR ACTIVATION ; GUT MICROBIOTA ; MAGNETIC-RESONANCE ; PHENOLIC-COMPOUNDS ; DISEASE ; LIVER ; TEA ; ABSORPTION ; SPECTROSCOPY |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000426144200013 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Key R&D Program of China(2017YFC0906800) ; National Key R&D Program of China(2017YFC0906800) ; National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006) ; National Key R&D Program of China(2017YFC0906800) ; National Key R&D Program of China(2017YFC0906800) ; National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006) ; National Key R&D Program of China(2017YFC0906800) ; National Key R&D Program of China(2017YFC0906800) ; National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006) ; National Key R&D Program of China(2017YFC0906800) ; National Key R&D Program of China(2017YFC0906800) ; National Natural Science Foundation of China(21577169 ; National Natural Science Foundation of China(21577169 ; 21635006) ; 21635006) |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/12864]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Zhang, Limin; Tang, Huiru; Wang, Yulan |
| 作者单位 | 1.Fudan Univ, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev, Shanghai Int Ctr Mol Phen,Zhongshan Hosp,Sch Life, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Peoples R China 3.Changzhou Univ, Sch Environm & Safety Engn, Changzhou 213164, Jiangsu, Peoples R China 4.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Limin,Dong, Manyuan,Xu, Guangyong,et al. Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(7):1723-1731. |
| APA | Zhang, Limin,Dong, Manyuan,Xu, Guangyong,Tian, Yuan,Tang, Huiru,&Wang, Yulan.(2018).Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(7),1723-1731. |
| MLA | Zhang, Limin,et al."Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.7(2018):1723-1731. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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