中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 武汉物理与数学研究所
  3. 中国科学院武汉物理与数学研究所
Fecal Metabolomics of Type 2 Diabetic Rats and Treatment with Gardenia jasminoides Ellis Based on Mass Spectrometry Technique

文献类型：期刊论文

作者Zhou, Yuan1,3; Men, Lihui1; Pi, Zifeng2; Wei, Mengying1; Song, Fengrui2; Zhao, Chunfang1; Liu, Zhiqiang2
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2018-02-14
卷号66期号:6页码:1591-1599
关键词G. Jasminoides Fecal Metabolomics Uplc-qtoe-ms Type 2 Diabetes
ISSN号0021-8561
DOI10.1021/acs.jafc.7b06082
文献子类Article
英文摘要Modern studies have indicated Gardenia jasminoides Ellis (G. jasminoides) showed positive effect in treating type 2 diabetes mellitus (T2DM). In this study, 60 streptozotocin-induced T2DM rats were divided into four groups: type 2 diabetes control group, geniposide-treated group, total iridoid glycosides-treated group, and crude extraction of gardenlae fructus-treated group. The other ten healthy rats were the healthy control group. During 12 weeks of treatment, rat's feces samples were collected for the metabolomics study based on mass spectrometry technique. On the basis of the fecal metabolomics method, 19 potential biomarkers were screened and their relative intensities in each group were compared. The results revealed G. jasminoides mainly regulated dysfunctions in phenylalanine metabolism, tryptophan metabolism, and secondary bile acid biosynthesis pathways induced by diabetes. The current study provides new insight for metabonomics methodology toward T2DM, and the results show. that feces can preferably reflect the liver and intestines disorders.
WOS关键词TRADITIONAL CHINESE MEDICINE ; SPHINGOLIPID METABOLISM ; CELL-DEATH ; ESI-MS ; GENIPOSIDE ; ACIDS ; IDENTIFICATION ; RECEPTOR ; 3-HYDROXY-3-METHYLOXINDOLE ; CHROMATOGRAPHY
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
语种英语
WOS记录号WOS:000425474000035
出版者AMER CHEMICAL SOC
资助机构National Natural Science Foundation of China(81373952 ; National Natural Science Foundation of China(81373952 ; 81473537) ; 81473537) ; National Natural Science Foundation of China(81373952 ; National Natural Science Foundation of China(81373952 ; 81473537) ; 81473537) ; National Natural Science Foundation of China(81373952 ; National Natural Science Foundation of China(81373952 ; 81473537) ; 81473537) ; National Natural Science Foundation of China(81373952 ; National Natural Science Foundation of China(81373952 ; 81473537) ; 81473537)
源URL[http://ir.wipm.ac.cn/handle/112942/12868]  
专题中国科学院武汉物理与数学研究所
通讯作者Song, Fengrui; Zhao, Chunfang
作者单位1.Jilin Univ, Sch Pharmaceut Sci, Changchun 130012, Jilin, Peoples R China
2.Chinese Acad Sci, Changchun Inst Appl Chem, Natl Ctr Mass Spectrometry Changchun & Jilin Prov, Key Lab Chinese Med Chem & Mass Spectrometry, Changchun 130022, Jilin, Peoples R China
3.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Yuan,Men, Lihui,Pi, Zifeng,et al. Fecal Metabolomics of Type 2 Diabetic Rats and Treatment with Gardenia jasminoides Ellis Based on Mass Spectrometry Technique[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(6):1591-1599.
APA Zhou, Yuan.,Men, Lihui.,Pi, Zifeng.,Wei, Mengying.,Song, Fengrui.,...&Liu, Zhiqiang.(2018).Fecal Metabolomics of Type 2 Diabetic Rats and Treatment with Gardenia jasminoides Ellis Based on Mass Spectrometry Technique.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(6),1591-1599.
MLA Zhou, Yuan,et al."Fecal Metabolomics of Type 2 Diabetic Rats and Treatment with Gardenia jasminoides Ellis Based on Mass Spectrometry Technique".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.6(2018):1591-1599.

入库方式： OAI收割

来源：武汉物理与数学研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。