Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives
文献类型：期刊论文
| 作者 | Li, Yu1; Shi, Qiuyan1; Shao, Jiajia2; Yuan, Yaping3; Yang, Zhigang1; Chen, Shizhen3; Zhou, Xin3; Wen, Shijun2; Jiang, Zhong-Xing1 |
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2018-03-25 |
| 卷号 | 148页码:279-290 |
| 关键词 | Salinomycin Nature Product Modification Staudinger Reaction Anti-cancer Drugs F-19 Mri K-ras Pathway |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2018.02.004 |
| 文献子类 | Article |
| 英文摘要 | To improve the druggability of salinomycin, a 20-epi-amino-20-deoxysalinomycin derivatives library was synthesized with high efficacy from which a few salinomycin derivatives with high potency and selectivity were identified through comprehensive cytotoxicity assay, including a fluorine-19 magnetic resonance sensitive tool molecule. Using a K-ras cellular model, salinomycin and its derivatives showed different molecular mode of action from literature reports. These results would be valuable for developing salinomycin-based cancer therapy. (C) 2018 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | ANTIBACTERIAL ACTIVITY ; ANTIPROLIFERATIVE ACTIVITY ; CANCER-CELLS ; SALINOMYCIN ; AMIDES ; CYTOTOXICITY ; ANTICANCER ; APOPTOSIS ; ESTERS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000428824700022 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 资助机构 | National Key Research and Development Program of China(2016YFC1304704) ; National Key Research and Development Program of China(2016YFC1304704) ; National Natural Science Foundation of China(21372181 ; National Natural Science Foundation of China(21372181 ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; 21572168) ; 21572168) ; National Key Research and Development Program of China(2016YFC1304704) ; National Key Research and Development Program of China(2016YFC1304704) ; National Natural Science Foundation of China(21372181 ; National Natural Science Foundation of China(21372181 ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; 21572168) ; 21572168) ; National Key Research and Development Program of China(2016YFC1304704) ; National Key Research and Development Program of China(2016YFC1304704) ; National Natural Science Foundation of China(21372181 ; National Natural Science Foundation of China(21372181 ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; 21572168) ; 21572168) ; National Key Research and Development Program of China(2016YFC1304704) ; National Key Research and Development Program of China(2016YFC1304704) ; National Natural Science Foundation of China(21372181 ; National Natural Science Foundation of China(21372181 ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics (Wuhan Institute of Physics and Mathematics) ; 21572168) ; 21572168) |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/12946]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Jiang, Zhong-Xing |
| 作者单位 | 1.Wuhan Univ, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Sch Pharmaceut Sci, Wuhan 430071, Hubei, Peoples R China 2.Sun Yat Sen Univ, Canc Ctr, State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yu,Shi, Qiuyan,Shao, Jiajia,et al. Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018,148:279-290. |
| APA | Li, Yu.,Shi, Qiuyan.,Shao, Jiajia.,Yuan, Yaping.,Yang, Zhigang.,...&Jiang, Zhong-Xing.(2018).Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,148,279-290. |
| MLA | Li, Yu,et al."Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 148(2018):279-290. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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