The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference
文献类型：期刊论文
| 作者 | Sun, Yong-Mei1,2,3; Chen, Rong-Xiang4; Li, Zhi-Fei1,2; Spijker, Sabine3; Zhai, Rong-Wei1,2; Yang, Shang-Chuan1,2 |
| 刊名 | CNS NEUROSCIENCE & THERAPEUTICS
 |
| 出版日期 | 2018-05-01 |
| 卷号 | 24期号:5页码:420-428 |
| 关键词 | Conditioned Place Preference Memory Maintenance Morphine Posterior Insula Somatosensory |
| ISSN号 | 1755-5930 |
| DOI | 10.1111/cns.12799 |
| 文献子类 | Article |
| 英文摘要 | The heterogeneous insular cortex plays an interoceptive role in drug addiction by signaling the availability of drugs of abuse. Here, we tested whether the caudal part of the multisensory posterior insula (PI) stores somatosensory-associated rewarding memories. Using Sprague Dawley rats as subjects, we first established a morphine-induced conditioned place preference (CPP) paradigm, mainly based on somatic cues. Secondly, an electrolytic lesion of the caudal portion of the PI was carried out before and after the establishment of CPP, respectively. Our data demonstrated that the caudal PI lesions disrupted the maintenance, but not the acquisition of morphine-induced CPP. Lesion or subtle disruption of the PI had no major impact on locomotor activity. These findings indicate that the caudal portion of the PI might be involved in either the storage or the retrieval of morphine CPP memory. |
| WOS关键词 | SECONDARY SOMATOSENSORY CORTEX ; BASOLATERAL AMYGDALA ; MEASURING REWARD ; DRUG-ADDICTION ; MEMORY ; INACTIVATION ; ORGANIZATION ; INHIBITION ; PARADIGM ; AVERSION |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000430058800006 |
| 出版者 | WILEY |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/12974]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Sun, Yong-Mei |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mechanisms, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Kunming, Yunnan, Peoples R China 3.Vrije Univ Amsterdam, Dept Mol & Cellular Neurobiol, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Amsterdam, Netherlands 4.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst, Wuhan Inst Phys & Math, Wuhan, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Yong-Mei,Chen, Rong-Xiang,Li, Zhi-Fei,et al. The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference[J]. CNS NEUROSCIENCE & THERAPEUTICS,2018,24(5):420-428. |
| APA | Sun, Yong-Mei,Chen, Rong-Xiang,Li, Zhi-Fei,Spijker, Sabine,Zhai, Rong-Wei,&Yang, Shang-Chuan.(2018).The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference.CNS NEUROSCIENCE & THERAPEUTICS,24(5),420-428. |
| MLA | Sun, Yong-Mei,et al."The caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference".CNS NEUROSCIENCE & THERAPEUTICS 24.5(2018):420-428. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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