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Interactions between amyloid beta peptide and lipid membranes

文献类型：期刊论文

作者Niu, Zheng1,2; Zhang, Zhengfeng1; Zhao, Weijing1; Yang, Jun1
刊名BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
出版日期2018-09-01
卷号1860期号:9页码:1663-1669
关键词Alzheimer's Disease Beta-amyloid Peptide Fibrillation Phospholipids Membrane Disruption Solid-state Nuclear Magnetic Resonance
ISSN号0005-2736
DOI10.1016/j.bbamem.2018.04.004
文献子类Review
英文摘要The presence of amyloid plaques in the brain is a typical characteristic of Alzheimer's disease (AD). Amyloid plaques are formed from the deposits of aggregated amyloid beta peptide (A beta). The toxicity induced by A beta aggregates is correlated with A beta-membrane interactions. The mutual influences between aggregation and membranes are complicated and unclear. In recent years advanced experiments and findings are emerging to give us more detailed information on A beta-membrane interactions. In this review, we mainly focus on the A beta-membrane interactions and membrane-induced A beta structures. The mechanism of A beta-membrane interactions is also summarized, which provides insights into the prevention and treatment of AD.
WOS关键词ALZHEIMERS-DISEASE ; A-BETA ; METAL-IONS ; GANGLIOSIDE CLUSTERS ; SECONDARY NUCLEATION ; PROTEIN AGGREGATION ; MECHANISTIC INSIGHT ; MOLECULAR-STRUCTURE ; CHANNEL FORMATION ; FIBRIL FORMATION
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:000442333600008
出版者ELSEVIER SCIENCE BV
资助机构National Natural Science Foundation of China(21173259 ; National Natural Science Foundation of China(21173259 ; 21405171 ; 21405171 ; 21425523 ; 21425523 ; 31627803) ; 31627803) ; National Natural Science Foundation of China(21173259 ; National Natural Science Foundation of China(21173259 ; 21405171 ; 21405171 ; 21425523 ; 21425523 ; 31627803) ; 31627803) ; National Natural Science Foundation of China(21173259 ; National Natural Science Foundation of China(21173259 ; 21405171 ; 21405171 ; 21425523 ; 21425523 ; 31627803) ; 31627803) ; National Natural Science Foundation of China(21173259 ; National Natural Science Foundation of China(21173259 ; 21405171 ; 21405171 ; 21425523 ; 21425523 ; 31627803) ; 31627803)
源URL[http://ir.wipm.ac.cn/handle/112942/13040]  
专题中国科学院武汉物理与数学研究所
通讯作者Yang, Jun
作者单位1.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China
2.Tech Univ Munich, Dept Chem, D-85748 Garching, Germany
推荐引用方式
GB/T 7714		 Niu, Zheng,Zhang, Zhengfeng,Zhao, Weijing,et al. Interactions between amyloid beta peptide and lipid membranes[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2018,1860(9):1663-1669.
APA Niu, Zheng,Zhang, Zhengfeng,Zhao, Weijing,&Yang, Jun.(2018).Interactions between amyloid beta peptide and lipid membranes.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,1860(9),1663-1669.
MLA Niu, Zheng,et al."Interactions between amyloid beta peptide and lipid membranes".BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1860.9(2018):1663-1669.

入库方式： OAI收割

来源：武汉物理与数学研究所

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