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Quantitative evaluation of pulmonary gas-exchange function using hyperpolarized Xe-129 CEST MRS and MRI

文献类型：期刊论文

作者Li, Haidong1,2; Zhang, Zhiying1,2; Zhao, Xiuchao1,2; Han, Yeqing1,2; Sun, Xianping1,2; Ye, Chaohui1,2; Zhou, Xin1,2
刊名NMR IN BIOMEDICINE
出版日期2018-09-01
卷号31期号:9
关键词Cest Cigarette Smoke Copd Gas Exchange Function Hyperpolarized Xenon Lung
ISSN号0952-3480
DOI10.1002/nbm.3961
文献子类Article
英文摘要Hyperpolarized Xe-129 gas MR has been a powerful tool for evaluating pulmonary structure and function due to the extremely high enhancement in spin polarization, the good solubility in the pulmonary parenchyma, and the excellent chemical sensitivity to its surrounding environment. Generally, the quantitative structural and functional information of the lung are evaluated using hyperpolarized Xe-129 by employing the techniques of chemical shift saturation recovery (CSSR) and xenon polarization transfer contrast (XTC). Hyperpolarized Xe-129 chemical exchange saturation transfer (Hyper-CEST) is another method for quantifying the exchange information of hyperpolarized Xe-129 by using the exchange of xenon signals according to its different chemical shifts, and it has been widely used in biosensor studies in vitro. However, the feasibility of using hyperpolarized Xe-129 CEST to quantify the pulmonary gas exchange function in vivo is still unclear. In this study, the technique of CEST was used to quantitatively evaluate the gas exchange in the lung globally and regionally via hyperpolarized Xe-129 MRS and MRI, respectively. A new parameter, the pulmonary apparent gas exchange time constant (T-app), was defined, and it increased from 0.63s to 0.95s in chronic obstructive pulmonary disease (COPD) rats (induced by cigarette smoke and lipopolysaccharide exposure) versus the controls with a significant difference (P=0.001). Additionally, the spatial distribution maps of T-app in COPD rats' pulmonary parenchyma showed a regionally obvious increase compared with healthy rats. These results indicated that hyperpolarized Xe-129 CEST MR was an effective method for globally and regionally quantifying the pulmonary gas exchange function, which would be helpful in diagnosing lung diseases that are related to gas exchange, such as COPD.
WOS关键词INDUCED LUNG INJURY ; MAGNETIC-RESONANCE ; CHEMICAL-SHIFTS ; DIFFUSION MRI ; BREATH-HOLD ; RAT MODEL ; IN-VIVO ; NMR ; MICROSTRUCTURE ; DISEASE
WOS研究方向Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
语种英语
WOS记录号WOS:000442593800007
出版者WILEY
资助机构Key Research Program of Frontier Sciences, CAS(QYZDY-SSW-SLH018) ; Key Research Program of Frontier Sciences, CAS(QYZDY-SSW-SLH018) ; National Key R&D Program of China(2016YFC1304700 ; National Key R&D Program of China(2016YFC1304700 ; National Natural Science Foundation of China(81625011 ; National Natural Science Foundation of China(81625011 ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; 2017YFA0505400) ; 2017YFA0505400) ; 81227902 ; 81227902 ; 81601491) ; 81601491) ; Key Research Program of Frontier Sciences, CAS(QYZDY-SSW-SLH018) ; Key Research Program of Frontier Sciences, CAS(QYZDY-SSW-SLH018) ; National Key R&D Program of China(2016YFC1304700 ; National Key R&D Program of China(2016YFC1304700 ; National Natural Science Foundation of China(81625011 ; National Natural Science Foundation of China(81625011 ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; 2017YFA0505400) ; 2017YFA0505400) ; 81227902 ; 81227902 ; 81601491) ; 81601491) ; Key Research Program of Frontier Sciences, CAS(QYZDY-SSW-SLH018) ; Key Research Program of Frontier Sciences, CAS(QYZDY-SSW-SLH018) ; National Key R&D Program of China(2016YFC1304700 ; National Key R&D Program of China(2016YFC1304700 ; National Natural Science Foundation of China(81625011 ; National Natural Science Foundation of China(81625011 ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; 2017YFA0505400) ; 2017YFA0505400) ; 81227902 ; 81227902 ; 81601491) ; 81601491) ; Key Research Program of Frontier Sciences, CAS(QYZDY-SSW-SLH018) ; Key Research Program of Frontier Sciences, CAS(QYZDY-SSW-SLH018) ; National Key R&D Program of China(2016YFC1304700 ; National Key R&D Program of China(2016YFC1304700 ; National Natural Science Foundation of China(81625011 ; National Natural Science Foundation of China(81625011 ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; National Program for Support of Eminent Professionals (National Program for Support of Top-notch Young Professionals) ; 2017YFA0505400) ; 2017YFA0505400) ; 81227902 ; 81227902 ; 81601491) ; 81601491)
源URL[http://ir.wipm.ac.cn/handle/112942/13050]  
专题中国科学院武汉物理与数学研究所
通讯作者Zhou, Xin
作者单位1.Univ Chinese Acad Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Natl Ctr Magnet Resonance Wuhan, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Li, Haidong,Zhang, Zhiying,Zhao, Xiuchao,et al. Quantitative evaluation of pulmonary gas-exchange function using hyperpolarized Xe-129 CEST MRS and MRI[J]. NMR IN BIOMEDICINE,2018,31(9).
APA Li, Haidong.,Zhang, Zhiying.,Zhao, Xiuchao.,Han, Yeqing.,Sun, Xianping.,...&Zhou, Xin.(2018).Quantitative evaluation of pulmonary gas-exchange function using hyperpolarized Xe-129 CEST MRS and MRI.NMR IN BIOMEDICINE,31(9).
MLA Li, Haidong,et al."Quantitative evaluation of pulmonary gas-exchange function using hyperpolarized Xe-129 CEST MRS and MRI".NMR IN BIOMEDICINE 31.9(2018).

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来源：武汉物理与数学研究所

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